This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Amithiozone
- DrugBank Accession Number
- DB12829
- Background
Amithiozone has been used in trials studying the treatment of Mycobacterium Avium-intracellulare Infection.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Amithiozone (DB12829)
- Weight
- Average: 236.29
Monoisotopic: 236.073182196 - Chemical Formula
- C10H12N4OS
- Synonyms
- Amithiozone
- Thioacetazone
- Thioacétazone
- Thioacetazonum
- Tioacetazona
- External IDs
- NSC-3550
- RP 4207
- SDT 1041
- SQ-2321
- TB I-698
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcenocoumarol The risk or severity of bleeding can be increased when Amithiozone is combined with Acenocoumarol. Ambroxol The risk or severity of methemoglobinemia can be increased when Amithiozone is combined with Ambroxol. Articaine The risk or severity of methemoglobinemia can be increased when Amithiozone is combined with Articaine. Bacillus calmette-guerin substrain russian BCG-I live antigen The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Amithiozone. BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Amithiozone. - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
Categories
- ATC Codes
- J04AM04 — Thioacetazone and isoniazid
- J04AM — Combinations of drugs for treatment of tuberculosis
- J04A — DRUGS FOR TREATMENT OF TUBERCULOSIS
- J04 — ANTIMYCOBACTERIALS
- J — ANTIINFECTIVES FOR SYSTEMIC USE
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as acetanilides. These are organic compounds containing an acetamide group conjugated to a phenyl group.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Anilides
- Direct Parent
- Acetanilides
- Alternative Parents
- N-acetylarylamines / Thiosemicarbazones / Acetamides / Secondary carboxylic acid amides / Organosulfur compounds / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Acetamide / Acetanilide / Aromatic homomonocyclic compound / Carbonyl group / Carboxamide group / Carboxylic acid derivative / Hydrocarbon derivative / N-acetylarylamine / N-arylamide / Organic nitrogen compound
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- MMG78X7SSR
- CAS number
- 104-06-3
- InChI Key
- SRVJKTDHMYAMHA-WUXMJOGZSA-N
- InChI
- InChI=1S/C10H12N4OS/c1-7(15)13-9-4-2-8(3-5-9)6-12-14-10(11)16/h2-6H,1H3,(H,13,15)(H3,11,14,16)/b12-6+
- IUPAC Name
- N-{4-[(E)-[(carbamothioylamino)imino]methyl]phenyl}acetamide
- SMILES
- CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1
References
- General References
- Not Available
- External Links
- PubChem Compound
- 9568512
- PubChem Substance
- 347828995
- ChemSpider
- 7843221
- ChEMBL
- CHEMBL375492
- ZINC
- ZINC000017970372
- Wikipedia
- Thioacetazone
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data2 Completed Treatment Mycobacterium avium complex infection 1 somestatus stop reason just information to hide Not Available Recruiting Not Available Tuberculosis (TB) 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet 150 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0505 mg/mL ALOGPS logP 1.75 ALOGPS logP 0.9 Chemaxon logS -3.7 ALOGPS pKa (Strongest Acidic) 11.71 Chemaxon pKa (Strongest Basic) 2.49 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 79.51 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 69.1 m3·mol-1 Chemaxon Polarizability 25.1 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-000i-0190000000-3c919bbfbbfbfea6cdbb Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0udi-0090000000-7896db2b20392a8bb47c Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0hiy-0900000000-2d3830e0080d38df0c4a Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0a4i-4910000000-8d00b6f69e2fa9f6f9c5 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-014i-0900000000-e90bc66a572a70a1a707 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-08fr-1900000000-97fe07db713826c8ed05 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 160.6973355 predictedDarkChem Lite v0.1.0 [M-H]- 159.17969 predictedDeepCCS 1.0 (2019) [M+H]+ 161.3767355 predictedDarkChem Lite v0.1.0 [M+H]+ 161.53769 predictedDeepCCS 1.0 (2019) [M+Na]+ 161.0781355 predictedDarkChem Lite v0.1.0 [M+Na]+ 167.63081 predictedDeepCCS 1.0 (2019)
Drug created at October 21, 2016 00:33 / Updated at June 12, 2020 16:53