Amithiozone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Amithiozone
DrugBank Accession Number
DB12829
Background

Amithiozone has been used in trials studying the treatment of Mycobacterium Avium-intracellulare Infection.

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 236.29
Monoisotopic: 236.073182196
Chemical Formula
C10H12N4OS
Synonyms
  • Amithiozone
  • Thioacetazone
  • Thioacétazone
  • Thioacetazonum
  • Tioacetazona
External IDs
  • NSC-3550
  • RP 4207
  • SDT 1041
  • SQ-2321
  • TB I-698

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcenocoumarolThe risk or severity of bleeding can be increased when Amithiozone is combined with Acenocoumarol.
Bacillus calmette-guerin substrain russian BCG-I live antigenThe therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Amithiozone.
BCG vaccineThe therapeutic efficacy of BCG vaccine can be decreased when used in combination with Amithiozone.
DicoumarolThe risk or severity of bleeding can be increased when Amithiozone is combined with Dicoumarol.
EstetrolThe therapeutic efficacy of Estetrol can be decreased when used in combination with Amithiozone.
FluindioneThe risk or severity of bleeding can be increased when Amithiozone is combined with Fluindione.
LactuloseThe therapeutic efficacy of Lactulose can be decreased when used in combination with Amithiozone.
MagnesiumThe serum concentration of Magnesium can be decreased when it is combined with Amithiozone.
PhenindioneThe risk or severity of bleeding can be increased when Amithiozone is combined with Phenindione.
PhenprocoumonThe risk or severity of bleeding can be increased when Amithiozone is combined with Phenprocoumon.
Interactions
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Food Interactions
Not Available

Products

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Categories

ATC Codes
J04AM04 — Thioacetazone and isoniazidJ04AK07 — Thioacetazone
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as acetanilides. These are organic compounds containing an acetamide group conjugated to a phenyl group.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Anilides
Direct Parent
Acetanilides
Alternative Parents
N-acetylarylamines / Thiosemicarbazones / Acetamides / Secondary carboxylic acid amides / Organosulfur compounds / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Acetamide / Acetanilide / Aromatic homomonocyclic compound / Carbonyl group / Carboxamide group / Carboxylic acid derivative / Hydrocarbon derivative / N-acetylarylamine / N-arylamide / Organic nitrogen compound
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
MMG78X7SSR
CAS number
104-06-3
InChI Key
SRVJKTDHMYAMHA-WUXMJOGZSA-N
InChI
InChI=1S/C10H12N4OS/c1-7(15)13-9-4-2-8(3-5-9)6-12-14-10(11)16/h2-6H,1H3,(H,13,15)(H3,11,14,16)/b12-6+
IUPAC Name
N-{4-[(E)-[(carbamothioylamino)imino]methyl]phenyl}acetamide
SMILES
CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1

References

General References
Not Available
PubChem Compound
9568512
PubChem Substance
347828995
ChemSpider
7843221
ChEMBL
CHEMBL375492
ZINC
ZINC000017970372
Wikipedia
Thioacetazone

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentInfection, Mycobacterium Avium-Intracellulare1
Not AvailableRecruitingNot AvailableTuberculosis (TB)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0505 mg/mLALOGPS
logP1.75ALOGPS
logP0.9ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)11.71ChemAxon
pKa (Strongest Basic)2.49ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area79.51 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity69.1 m3·mol-1ChemAxon
Polarizability25.1 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on October 21, 2016 00:33 / Updated on June 12, 2020 16:53