Carboxypeptidase A1

BE0003753ProteinHumansCPA1

Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (PubMed:20385563, PubMed:8806703). It is acted on by 14 drugs in DrugBank.

Gene name
CPA1
UniProtKB entry
P15085Swiss-Prot
Cellular location
Secreted
Residues / weight
419 residues · 47,140 Da
Also known as
3.4.17.1 · CPA

Resolves to

Protein
UniProtP15085UniProt nameCBPA1_HUMAN
Gene
HGNCHGNC:2296NCBI Gene1357GenBank35330GeneCardsCPA1
Pharmacology
IUPHAR/GtoPdb1587KEGGhsa:1357
Structure
PDB2V77PDB3FJUPDB4UEE
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carboxypeptidase A1, how selective are they, and which programs against it are still in active trials?

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