Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in... Hirudin is a single polypeptide chain of 65 amino acids residues and contains three disulfide bridges.
- Mechanism
- Curator reviewed
Desirudin is a direct, highly selective thrombin inhibitor. Reversibly binds to the active thrombin site of free and clot-associated thrombin. Inhibits fibrin formation, activation of coagulation factors V, VII, and XIII, and thrombin-induced platelet aggregation resulting in a dose-dependent prolongation of the activated partial thromboplastin time (aPTT).
- Primary indication
- Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.Curator reviewed · 1 structured indication
- Formula / weight
- C287H440N80O110S6
- First approval
- United States, 2010
- Also known as
- 63-Desulfohirudin · 63-Desulfohirudin (Hirudo Medicinalis Isoform HV1) · 63-Desulfohirudin (recombinant) · Desirudin recombinant · Hirudin desirudin
- Code names
- CGP-39393
Resolves to
What you can answer from here — as of June 15, 2026
Which drugs share a target with Desirudin, and which of those have an active Phase 3 trial?
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