cAMP-dependent protein kinase inhibitor alpha

BE0003762ProteinHumansPKIA

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. It is acted on by 30 drugs in DrugBank.

Gene name
PKIA
UniProtKB entry
P61925Swiss-Prot
Residues / weight
76 residues · 7,988 Da
Also known as
cAMP-dependent protein kinase inhibitor, muscle/brain isoform · PKI-alpha · PRKACN1

Resolves to

Protein
UniProtP61925UniProt nameIPKA_HUMAN
Gene
HGNCHGNC:9017NCBI Gene5569GenBank243494GeneCardsPKIA
Pharmacology
KEGGhsa:5569
Structure
PDB1CMKPDB1JLUPDB1Q8T
Drugs

What you can answer from here — as of September 07, 2019

30DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which compounds in development act on cAMP-dependent protein kinase inhibitor alpha, and which indications are they being tested in?

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