Ninvosudil

DB08756InvestigationalSmall molecule

Y-27632 is an inhibitor of Rho-associated protein kinase. It inhibits calcium sensitization to affect smooth muscle relaxation.

Chemical structure of Ninvosudil
Formula / weight
C14H21N3O · 247.336 g/mol (avg)
Also known as
(R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide · 4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide
Code names
J888.082D · Y-27632

Resolves to

Compound
UNII0X370ROP6HCAS146986-50-7ChEMBLCHEMBL559147ChEBI75393PubChem448042
Structure
InChIKeyIYOZTVGMEWJPKR-IJLUTSLNSA-NSMILES[H][C@@]1(CC[C@@H](CC1)C(=O)NC1=CC=NC=C1)[C@@H](C)N
Targets
P17612PRKACAP61925PKIAQ13464ROCK1O75116ROCK2

What you can answer from here — as of September 23, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action
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4Clinical trialsPhase, status and sponsor resolved per trial
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4+ReferencesStructured and connected to the statements they support
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