Heat shock cognate 71 kDa protein

BE0003775ProteinHumansHSPA8

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation... It is acted on by 7 drugs in DrugBank.

Gene name
HSPA8
UniProtKB entry
P11142Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
646 residues · 70,898 Da
Also known as
3.6.4.10 · Heat shock 70 kDa protein 8 · Heat shock protein family A member 8 · HSC70 · HSP73

Resolves to

Protein
UniProtP11142UniProt nameHSP7C_HUMAN
Gene
HGNCHGNC:5241NCBI Gene3312GenBank11526573GeneCardsHSPA8
Pharmacology
KEGGhsa:3312
Structure
PDB3AGYPDB3AGZPDB3ESK
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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53+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Heat shock cognate 71 kDa protein, how selective are they, and which programs against it are still in active trials?

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