Oxysterols receptor LXR-alpha

BE0003781ProteinHumansNR1H3

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920, PubMed:37478846). It is acted on by 11 drugs in DrugBank.

Gene name
NR1H3
UniProtKB entry
Q13133Swiss-Prot
Cellular location
Nucleus
Residues / weight
447 residues · 50,395 Da
Also known as
Liver X receptor alpha · LXRA · Nuclear receptor subfamily 1 group H member 3

Resolves to

Protein
UniProtQ13133UniProt nameNR1H3_HUMAN
Gene
HGNCHGNC:7966NCBI Gene10062GenBank726513GeneCardsNR1H3
Pharmacology
IUPHAR/GtoPdb602KEGGhsa:10062
Structure
PDB1UHLPDB3IPQPDB3IPS
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Oxysterols receptor LXR-alpha, how selective are they, and which programs against it are still in active trials?

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