Dual specificity protein kinase TTK

BE0003791ProteinHumansTTK

Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). It is acted on by 6 drugs in DrugBank.

Gene name
TTK
UniProtKB entry
P33981Swiss-Prot
Residues / weight
857 residues · 97,072 Da
Also known as
2.7.12.1 · MPS1 · MPS1L1 · Phosphotyrosine picked threonine-protein kinase · PYT

Resolves to

Protein
UniProtP33981UniProt nameTTK_HUMAN
Gene
HGNCHGNC:12401NCBI Gene7272GenBank340011GeneCardsTTK
Pharmacology
IUPHAR/GtoPdb2264KEGGhsa:7272
Structure
PDB2X9EPDB2ZMCPDB2ZMD
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dual specificity protein kinase TTK, how selective are they, and which programs against it are still in active trials?

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