Serine/threonine-protein kinase Nek2

BE0003796ProteinHumansNEK2

Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. It is acted on by 2 drugs in DrugBank.

Gene name
NEK2
UniProtKB entry
P51955Swiss-Prot
Cellular location
Nucleus
Residues / weight
445 residues · 51,763 Da
Also known as
2.7.11.1 · HSPK 21 · NEK2A · Never in mitosis A-related kinase 2 · NimA-like protein kinase 1

Resolves to

Protein
UniProtP51955UniProt nameNEK2_HUMAN
Gene
HGNCHGNC:7745NCBI Gene4751GenBank479171GeneCardsNEK2
Pharmacology
IUPHAR/GtoPdb2117KEGGhsa:4751
Structure
PDB2JAVPDB2W5APDB2W5B
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase Nek2, how selective are they, and which programs against it are still in active trials?

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