ATP synthase F(1) complex subunit beta, mitochondrial

BE0003841ProteinHumansATP5F1B

Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by... It is acted on by 7 drugs in DrugBank.

Gene name
ATP5F1B
UniProtKB entry
P06576Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
529 residues · 56,559 Da
Also known as
7.1.2.2 · ATP synthase F1 subunit beta · ATP5B · ATPMB · ATPSB

Resolves to

Protein
UniProtP06576UniProt nameATPB_HUMAN
Gene
HGNCHGNC:830NCBI Gene506GenBank28940GeneCardsATP5F1B
Pharmacology
KEGGhsa:506
Structure
PDB8H9EPDB8H9IPDB8H9L
Drugs

What you can answer from here — as of June 26, 2025

7DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP synthase F(1) complex subunit beta, mitochondrial, how selective are they, and which programs against it are still in active trials?

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