Quercetin

DB04216InvestigationalSmall molecule

Quercetin is a natural flavonoid found in foods and natural supplement products. Quercetin is a flavonol widely distributed in plants.

Mechanism: Quercetin is a specific quinone reductase 2 (QR2) inhibitor, an enzyme (along with the human QR1 homolog) which catalyzes metabolism of toxic quinolines. Inhibition of QR2 in plasmodium may potentially cause lethal oxidative stress. The inhibition of antioxidant activity in plasmodium may contribute to killing the malaria causing parasites.
Curator reviewed
Formula / weight: C₁₅H₁₀O₇ · 302.2357 g/mol (avg)
Also known as: 3'-HYDROXYKAEMPFEROL · FLAVONE, 3,3',4',5,7-PENTAHYDROXY- · poly (lactide-co-glycolide)-polyethylene glycol nanoparticles encapsulating quercetin · Sophoretin · Xanthaurine
Code names: LDN-0052529 · NSC-57655 · NSC-9219

Resolves to

Compound

UNII9IKM0I5T1ECAS117-39-5ChEMBLCHEMBL50ChEBI16243PubChem5280343KEGGC00389

Clinical / RWD

RxNorm9060

Structure

InChIKeyREFJWTPEDVJJIY-UHFFFAOYSA-NSMILESOC1=CC2=C(C(O)=C1)C(=O)C(O)=C(O2)C1=CC=C(O)C(O)=C1

Targets

P40763STAT3Q7L5N7LPCAT2Q8NF37LPCAT1P48736PIK3CGQ6NUS8UGT3A1P25705ATP5F1AP06576ATP5F1BP36542ATP5F1C+24 more

Transporters

P33527ABCC1Q92887ABCC2O60669SLC16A7O94956SLCO2B1P08183ABCB1P53985SLC16A1Q9UNQ0ABCG2Q9Y6L6SLCO1B1

What you can answer from here — as of September 23, 2026

32Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

8TransportersSubstrate / inhibitor direction, not just membership

Listed above

562Drug interactionsStructured to mechanism, not free text

59Clinical trialsPhase, status and sponsor resolved per trial

1Marketed productAcross 1 country and 1 labeller

99+ReferencesStructured and connected to the statements they support

Which drugs share a target with Quercetin, and which of those have an active Phase 3 trial?

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