[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

BE0003862ProteinHumansPDK1

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). It is acted on by 4 drugs in DrugBank.

Gene name
PDK1
UniProtKB entry
Q15118Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
436 residues · 49,244 Da
Also known as
2.7.11.2 · PDH kinase 1 · PDHK1 · Pyruvate dehydrogenase kinase isoform 1

Resolves to

Protein
UniProtQ15118UniProt namePDK1_HUMAN
Gene
HGNCHGNC:8809NCBI Gene5163GenBank1088281GeneCardsPDK1
Pharmacology
IUPHAR/GtoPdb2915KEGGhsa:5163
Structure
PDB2Q8FPDB2Q8GPDB2Q8H
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial, how selective are they, and which programs against it are still in active trials?

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