Dichloroacetic acid

DB08809ApprovedInvestigationalWithdrawnSmall molecule

Dichloroacetic acid, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms.... Salts of DCA are used as drugs since they inhibit the enzyme pyruvate dehydrogenase kinase.

Chemical structure of Dichloroacetic acid
Mechanism
Curator reviewed
Formula / weight
C2H2Cl2O2 · 128.942 g/mol (avg)
First approval
Canada, 1989
Also known as
Dichloracetic acid · Dichloroacetate

Resolves to

Compound
UNII9LSH52S3LQCAS79-43-6ChEMBLCHEMBL13960ChEBI36386PubChem6597KEGGC11149
Clinical / RWD
RxNorm155021PharmGKBPA165947835
Structure
InChIKeyJXTHNDFMNIQAHM-UHFFFAOYSA-NSMILESOC(=O)C(Cl)Cl
Targets
Q15118PDK1O43708GSTZ1

What you can answer from here — as of July 17, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
25Clinical trialsPhase, status and sponsor resolved per trial
Sign in
1Marketed productAcross 1 country and 1 labeller
Sign in
5+ReferencesStructured and connected to the statements they support
Sign in

Which drugs share a target with Dichloroacetic acid, and which of those have an active Phase 3 trial?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In