Disintegrin and metalloproteinase domain-containing protein 28

BE0003872ProteinHumansADAM28

May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. It is acted on by 7 drugs in DrugBank.

Gene name
ADAM28
UniProtKB entry
Q9UKQ2Swiss-Prot
Cellular location
Cell membrane
Residues / weight
775 residues · 87,147 Da
Also known as
3.4.24.- · ADAM 28 · ADAM23 · eMDC II · Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II

Resolves to

Protein
UniProtQ9UKQ2UniProt nameADA28_HUMAN
Gene
HGNCHGNC:206NCBI Gene10863GenBank4583505GeneCardsADAM28
Pharmacology
KEGGhsa:10863
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Disintegrin and metalloproteinase domain-containing protein 28, how selective are they, and which programs against it are still in active trials?

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