Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

BE0003888ProteinHumansATP2A1

Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. It is acted on by 6 drugs in DrugBank.

Gene name
ATP2A1
UniProtKB entry
O14983Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
1,001 residues · 110,251 Da
Also known as
7.2.2.10 · Calcium pump 1 · Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform · Endoplasmic reticulum class 1/2 Ca(2+) ATPase · SERCA1

Resolves to

Protein
UniProtO14983UniProt nameAT2A1_HUMAN
Gene
HGNCHGNC:811NCBI Gene487GenBank158256064GeneCardsATP2A1
Pharmacology
IUPHAR/GtoPdb840KEGGhsa:487
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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28GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, how selective are they, and which programs against it are still in active trials?

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