Protein kinase C iota type

BE0003889ProteinHumansPRKCI

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the... It is acted on by 3 drugs in DrugBank.

Gene name
PRKCI
UniProtKB entry
P41743Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
596 residues · 68,262 Da
Also known as
2.7.11.13 · aPKC-lambda/iota · Atypical protein kinase C-lambda/iota · DXS1179E · nPKC-iota

Resolves to

Protein
UniProtP41743UniProt nameKPCI_HUMAN
Gene
HGNCHGNC:9404NCBI Gene5584GenBank432274GeneCardsPRKCI
Pharmacology
IUPHAR/GtoPdb1490KEGGhsa:5584
Structure
PDB1VD2PDB1WMHPDB1ZRZ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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34GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein kinase C iota type, how selective are they, and which programs against it are still in active trials?

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