Casein kinase II subunit alpha'

BE0003984ProteinHumansCSNK2A2

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:30898438). It is acted on by 2 drugs in DrugBank.

Gene name
CSNK2A2
UniProtKB entry
P19784Swiss-Prot
Cellular location
Nucleus
Residues / weight
350 residues · 41,213 Da
Also known as
2.7.11.1 · CK II alpha' · CK2A2

Resolves to

Protein
UniProtP19784UniProt nameCSK22_HUMAN
Gene
HGNCHGNC:2459NCBI Gene1459GenBank177838GeneCardsCSNK2A2
Pharmacology
IUPHAR/GtoPdb1550KEGGhsa:1459
Structure
PDB3E3BPDB3OFMPDB3U87
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Casein kinase II subunit alpha', how selective are they, and which programs against it are still in active trials?

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