Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

BE0003986ProteinHumansCOX4I1

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. It is acted on by 2 drugs in DrugBank.

Gene name
COX4I1
UniProtKB entry
P13073Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
169 residues · 19,577 Da
Also known as
COX IV-1 · COX4 · Cytochrome c oxidase polypeptide IV · Cytochrome c oxidase subunit IV isoform 1

Resolves to

Protein
UniProtP13073UniProt nameCOX41_HUMAN
Gene
HGNCHGNC:2265NCBI Gene1327GenBank180933GeneCardsCOX4I1
Pharmacology
KEGGhsa:1327
Structure
PDB5Z62PDB9I6FPDB9I7U
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome c oxidase subunit 4 isoform 1, mitochondrial, how selective are they, and which programs against it are still in active trials?

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