Cholic Acid is a bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function. A major primary bile acid produced in the liver and usually conjugated with glycine or taurine.
- Mechanism
- Curator reviewed
Pharmacologically active on Phospholipase A2, Ferrochelatase, mitochondrial, and Liver carboxylesterase 1
- Primary indication
- Oral cholic acid is indicated for: treatment of bile acid synthesis disorders due to single enzyme defects; and as adjunctive treatment of peroxisomal disorders including Zellweger spectrum disorders in patients who exhibit manifestations of liver...Curator reviewed · 5 structured indications
- Formula / weight
- C24H40O5 · 408.5714 g/mol (avg)
- First approval
- United States, 2015 · European Union, 2016
- Code names
- E1000
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
BHQCQFFYRZLCQQ-OELDTZBJSA-NSMILES[H][C@@](C)(CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@]([H])(O)C[C@]4([H])C[C@]([H])(O)CC[C@]4(C)[C@@]3([H])C[C@]([H])(O)[C@]12CTargets
What you can answer from here — as of September 23, 2026
22Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
13TransportersSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Cholic Acid, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account