Cytochrome c oxidase subunit 8A, mitochondrial

BE0003993ProteinHumansCOX8A

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. It is acted on by 3 drugs in DrugBank.

Gene name
COX8A
UniProtKB entry
P10176Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
69 residues · 7,579 Da
Also known as
COX8 · COX8L · Cytochrome c oxidase polypeptide VIII-liver/heart · Cytochrome c oxidase subunit 8-2

Resolves to

Protein
UniProtP10176UniProt nameCOX8A_HUMAN
Gene
HGNCHGNC:2294NCBI Gene1351GenBank38614453GeneCardsCOX8A
Pharmacology
KEGGhsa:1351
Structure
PDB5Z62PDB8D4TPDB9I6F
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
5GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
6+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Cytochrome c oxidase subunit 8A, mitochondrial, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In