Dihydrofolate reductase 2, mitochondrial

BE0004001ProteinHumansDHFR2

Key enzyme in folate metabolism. It is acted on by 9 drugs in DrugBank.

Gene name
DHFR2
UniProtKB entry
Q86XF0Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
187 residues · 21,620 Da
Also known as
DHFRL1 · DHFRP4 · Dihydrofolate reductase-like protein 1 · Dihydrofolate reductase, mitochondrial

Resolves to

Protein
UniProtQ86XF0UniProt nameDYR2_HUMAN
Gene
HGNCHGNC:27309NCBI Gene200895GenBank50949491GeneCardsDHFR2
Pharmacology
KEGGhsa:200895
Drugs

What you can answer from here — as of September 03, 2024

9DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dihydrofolate reductase 2, mitochondrial, and which indications are they being tested in?

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