Dual specificity tyrosine-phosphorylation-regulated kinase 1A

BE0004012ProteinHumansDYRK1A

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). It is acted on by 8 drugs in DrugBank.

Gene name
DYRK1A
UniProtKB entry
Q13627Swiss-Prot
Cellular location
Nucleus
Residues / weight
763 residues · 85,583 Da
Also known as
2.7.11.23 · 2.7.12.1 · Dual specificity YAK1-related kinase · DYRK · hMNB

Resolves to

Protein
UniProtQ13627UniProt nameDYR1A_HUMAN
Gene
HGNCHGNC:3091NCBI Gene1859GenBank1381156GeneCardsDYRK1A
Pharmacology
IUPHAR/GtoPdb2009KEGGhsa:1859
Structure
PDB2VX3PDB2WO6PDB3ANQ
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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20GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dual specificity tyrosine-phosphorylation-regulated kinase 1A, how selective are they, and which programs against it are still in active trials?

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