Hepatocyte nuclear factor 4-alpha

BE0004019ProteinHumansHNF4A

Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). It is acted on by 6 drugs in DrugBank.

Gene name
HNF4A
UniProtKB entry
P41235Swiss-Prot
Cellular location
Nucleus
Residues / weight
474 residues · 52,784 Da
Also known as
HNF-4-alpha · HNF4 · NR2A1 · Nuclear receptor subfamily 2 group A member 1 · TCF-14

Resolves to

Protein
UniProtP41235UniProt nameHNF4A_HUMAN
Gene
HGNCHGNC:5024NCBI Gene3172GenBank1595752GeneCardsHNF4A
Pharmacology
IUPHAR/GtoPdb608KEGGhsa:3172
Structure
PDB1PZLPDB3CBBPDB3FS1
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hepatocyte nuclear factor 4-alpha, how selective are they, and which programs against it are still in active trials?

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