Protein TonB

BE0004021ProteinEscherichia coli (strain K12)tonB

Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin,... It is acted on by 4 drugs in DrugBank.

Gene name
tonB
UniProtKB entry
P02929Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
239 residues · 26,094 Da
Also known as
exbA

Resolves to

Protein
UniProtP02929UniProt nameTONB_ECOLI
Gene
NCBI Gene945843GenBank148023
Pharmacology
KEGGecj:JW5195
Structure
PDB1IHRPDB1QXXPDB1U07
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein TonB, how selective are they, and which programs against it are still in active trials?

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