Group IID secretory phospholipase A2

BE0004022ProteinHumansPLA2G2D

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed:10681567). It is acted on by 2 drugs in DrugBank.

Gene name
PLA2G2D
UniProtKB entry
Q9UNK4Swiss-Prot
Cellular location
Secreted
Residues / weight
145 residues · 16,546 Da
Also known as
3.1.1.4 · GIID sPLA2 · Phosphatidylcholine 2-acylhydrolase 2D · PLA2IID · Secretory-type PLA, stroma-associated homolog

Resolves to

Protein
UniProtQ9UNK4UniProt namePA2GD_HUMAN
Gene
HGNCHGNC:9033NCBI Gene26279GenBank5771420GeneCardsPLA2G2D
Pharmacology
IUPHAR/GtoPdb1418KEGGhsa:26279
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Group IID secretory phospholipase A2, how selective are they, and which programs against it are still in active trials?

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