Acyl-homoserine lactone acylase PvdQ

BE0004023ProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)pvdQ

Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. It is acted on by 1 drug in DrugBank.

Gene name
pvdQ
UniProtKB entry
Q9I194Swiss-Prot
Cellular location
Periplasm
Residues / weight
762 residues · 84,039 Da
Also known as
3.5.1.97 · AHL acylase PvdQ · qsc112

Resolves to

Protein
UniProtQ9I194UniProt namePVDQ_PSEAE
Gene
NCBI Gene882260GenBank9945819
Pharmacology
KEGGpae:PA2385
Structure
PDB2WYBPDB2WYCPDB2WYD
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acyl-homoserine lactone acylase PvdQ, how selective are they, and which programs against it are still in active trials?

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