Dual specificity protein kinase CLK3

BE0004043ProteinHumansCLK3

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. It is acted on by 4 drugs in DrugBank.

Gene name
CLK3
UniProtKB entry
P49761Swiss-Prot
Cellular location
Nucleus
Residues / weight
490 residues · 58,588 Da
Also known as
2.7.12.1 · CDC-like kinase 3

Resolves to

Protein
UniProtP49761UniProt nameCLK3_HUMAN
Gene
HGNCHGNC:2071NCBI Gene1198GenBank632970GeneCardsCLK3
Pharmacology
IUPHAR/GtoPdb1992KEGGhsa:1198
Structure
PDB29MOPDB29MPPDB2EU9
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dual specificity protein kinase CLK3, how selective are they, and which programs against it are still in active trials?

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