Elongation factor-like GTPase 1

BE0004053ProteinHumansEFL1

GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. It is acted on by 3 drugs in DrugBank.

Gene name
EFL1
UniProtKB entry
Q7Z2Z2Swiss-Prot
Residues / weight
1,120 residues · 125,429 Da
Also known as
3.6.5.- · EFTUD1 · Elongation factor Tu GTP-binding domain-containing protein 1 · Elongation factor-like 1 · FAM42A

Resolves to

Protein
UniProtQ7Z2Z2UniProt nameEFL1_HUMAN
Gene
HGNCHGNC:25789NCBI Gene79631GenBank10434992GeneCardsEFL1
Pharmacology
KEGGhsa:79631
Structure
PDB5ANBPDB5ANC
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Elongation factor-like GTPase 1, how selective are they, and which programs against it are still in active trials?

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