Serine/threonine-protein kinase Sgk1

BE0004105ProteinHumansSGK1

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. It is acted on by 6 drugs in DrugBank.

Gene name
SGK1
UniProtKB entry
O00141Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
431 residues · 48,942 Da
Also known as
2.7.11.1 · Serum/glucocorticoid-regulated kinase 1 · SGK

Resolves to

Protein
UniProtO00141UniProt nameSGK1_HUMAN
Gene
HGNCHGNC:10810NCBI Gene6446GenBank1834511GeneCardsSGK1
Pharmacology
IUPHAR/GtoPdb1534KEGGhsa:6446
Structure
PDB2R5TPDB3HDMPDB3HDN
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
68+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Serine/threonine-protein kinase Sgk1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In