Enolase-phosphatase E1

BE0004122ProteinHumansENOPH1

Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). It is acted on by 2 drugs in DrugBank.

Gene name
ENOPH1
UniProtKB entry
Q9UHY7Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
261 residues · 28,932 Da
Also known as
2,3-diketo-5-methylthio-1-phosphopentane phosphatase · 3.1.3.77 · MASA · MASA homolog

Resolves to

Protein
UniProtQ9UHY7UniProt nameENOPH_HUMAN
Gene
HGNCHGNC:24599NCBI Gene58478GeneCardsENOPH1
Pharmacology
KEGGhsa:58478
Structure
PDB1YNSPDB1ZS9
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Enolase-phosphatase E1, how selective are they, and which programs against it are still in active trials?

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