Sodium fluoride

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Identification

Summary

Sodium fluoride is an ingredient of various dental preparations used to support tooth mineralization and the prevention of dental caries.

Brand Names

60 Second Taste, Clinpro 5000, Ctx4 Gel, Denta 5000 Plus, Denticare Neutral, Denticare Pro Gel, Fluorishield, Fluoritab, Flura-drops, Gelato Sodium Fluoride, Kolorz, Ludent, Meijer, Mvc-fluoride, Neutracare, Neutramaxx, Oral-B Minute-foam, Oral-B Neutra, Pcxx Neutral Foam, Pcxx Neutral Rinse, Perfect Choice One Minute, Prevident, Prevident 5000 Sensitive, Prevident Dental Rinse, Prodenrx Rinse, Zooby Fluoride Foam

Generic Name

Sodium fluoride

DrugBank Accession Number

DB09325

Background

Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as Fluoride ion F-18.¹⁷ Sodium fluoride's benefits on dental health were first observed in the 1930s, when individuals in communities with fluoridated drinking water showed less tooth decay than those without fluoridated water. The use of fluoride in dental practice began in the 1940s. Now, sodium fluoride may be found in a variety of gels, varnishes, rinses, toothpaste products, and fluoride treatments provided in dental care.^5,6 According to the American Dental Association (ADA), thorough evidence reviews have indicated that the use of fluoride to prevent and control dental caries is safe when used correctly and is highly effective in reducing the prevalence of caries.¹⁹

Type

Small Molecule

Groups

Approved

Structure

Similar Structures

Weight: Average: 41.9882
Monoisotopic: 41.98817288
Chemical Formula: FNa

Synonyms

Sodium fluoride

External IDs

NSC-77385

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Pharmacology

Indication

Sodium fluoride in the oral or topical form is indicated for the prevention and control of dental caries and for the maintenance of dental health.^1,12 Fluoride supplements in the form of tablets and other formulas may be prescribed to prevent tooth decay in high-risk children aged 6 months to 16 years old whose drinking water source contains low fluoride concentrations.¹⁹

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Dose Form
Used in combination to treat	Caries; enamel	Combination Product in combination with: Dectaflur (DB16622), Olaflur (DB13290), Sodium fluoride (DB09325)	••• •••	•••
Used in combination to prevent	Cavity	Combination Product in combination with: Potassium nitrate (DB11090)	••• •••
Prevention of	Dental caries		••• •••
Used in combination to treat	Dental cavity	Combination Product in combination with: Dectaflur (DB16622), Olaflur (DB13290), Sodium fluoride (DB09325)	••• •••	•••
Maintenance of	Dental health		••• •••••• ••• •••

Associated Therapies

Parenteral Nutrition

Contraindications & Blackbox Warnings

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Pharmacodynamics

Sodium fluoride protects the teeth from acid demineralization while preventing tooth decay by bacteria while strengthening tooth enamel.^2,6 It is important to note that excess fluoride exposure during tooth mineralization, especially in children 1-3 years old, may cause fluorosis. It is a condition manifested by white lines, pitting, or discoloration of teeth resulting from changes in tooth enamel.^8,18 The risk of fluorosis can be decreased by the use of a rice-size amount of fluoridated toothpaste in children younger than 3 years old. It is recommended that no more than a pea-sized quantity of fluoridated toothpaste should be used for children from 3 to 6 years old.¹⁸ The American Dentistry Association (ADA) recommends that children should be closely supervised during toothpaste use to prevent excess fluoride ingestion.¹⁹

Mechanism of action

The prevention of dental caries by topical fluoride is achieved by various mechanisms.⁹ Sodium fluoride kills bacteria that cause caries, such a Streptococcus mutans and lactobacilli¹⁰ by interfering with their metabolic activities that result in the formation of lactic acid. Fluoride ions cause the inhibition of glycolytic and other enzymes involved in bacterial metabolism. It changes the permeability of cell membranes, lowering the pH in the cytoplasm of the cell, leading to a decrease in acidity, which is normally implicated in tooth decay.¹

When administered at low topical doses, fluoride in both saliva and plaque and saliva prevent the demineralization of healthy tooth enamel while remineralizing teeth that have previously been demineralized. Sodium fluoride is absorbed by the surface of hydroxyapatite crystals on the teeth, which are necessary for mineralization. This renders the teeth more resistant to demineralization by changing the apatite crystal solubility.^5,7 Sodium fluoride inhibits the demineralization of teeth in a pH-related manner. When used in high doses, in formulations such as the fluoride varnishes or gels, sodium fluoride forms a layer on the surface of tooth enamel. When the pH of the mouth is reduced due to acid production by bacteria such as S.mutans, fluoride is released, interfering with bacterial metabolism, and then acts to remineralize the teeth.^1,7,18

Target	Actions	Organism
UHydroxyapatite	Not Available	Humans

Absorption

Sodium fluoride is 90% absorbed from the gastrointestinal tract, with 77% of absorption in the proximal intestine and about 25% in the stomach. The rate of absorption may vary according to gastric pH. Cmax is reached 20-60 minutes after ingestion.³ Cmax was estimated to be 848 ± 116 ng/mL after a 20mg sodium fluoride solution was ingested, with a Tmax of 0.46 ± 0.17 hours.¹ The bioavailability of sodium fluoride tablets administered in the fasted state during one pharmacokinetic study approached 100%.³ Another resource reports a sodium fluoride AUC of 1.14 ± 0.12 μg × h/mL after the ingestion of fluoridated water.⁴

Volume of distribution

Fluoride distributes to the saliva, bones, and teeth, and is also found in lesser quantities in the breastmilk and sweat.¹ After the ingestion of sodium fluoridated drinking water, the fluoride ions are found to distribute to the plasma and blood cells. Plasma levels of fluoride concentrations are twice as the concentrations found in blood cells.¹⁶ Adults have been found to retain 36% of ingested fluoride and children have been found to retain about 50% of a dose. Most of the retained fluoride is localized to bone and teeth and 1% accumulates in soft tissues.¹ Fluoride crosses the placenta and the blood-brain barrier. The central nervous system concentrations of sodium fluoride are estimated to reach 20% the plasma concentrations.¹⁶ Studies conducted in communities with high levels of fluoride in water did not show any increase in birth defects.¹² The placenta is able to regulate the accumulation of excess fluoride, possibly protecting the fetus from high levels of fluoride.⁵ Despite this, excessively high exposure to fluoride in utero may lead to skeletal fluorosis.¹²

Protein binding

Fluoride ions are bound to plasma proteins.¹ The percentage of protein binding is not readily available in the evaluated literature.

Metabolism

Several factors can affect the metabolism of sodium fluoride. These include disorders of acid-base balance, circadian rhythm, hematocrit level, high or low altitude, the level physical activity, hormonal status, renal function, genetic predispositions in addition to the diet.¹

Route of elimination

Sodium fluoride is rapidly excreted, mainly in the urine. About 90% of fluoride is filtered by the glomerulus and reabsorbed by the renal tubules. About 10% is excreted in the feces.¹

Half-life

The terminal plasma elimination half-life following the ingestion of fluoridated drinking water generally ranges from 3 to 10 hours.¹⁶ The half-life of sodium fluoride in the bones is 20 years.²⁰

Clearance

Sodium fluoride is rapidly cleared by the kidneys and depends on various factors, including glomerular filtration rate, urine flow, and urine pH.¹⁶ According to one clinical study evaluating the pharmacokinetics of oral sodium fluoride tablets in healthy young adults, the renal clearance was determined to be 77.4 ± 11.2mL/min for acidic urine and 78.4 ± 6.9mL/min for alkaline urine.³ Another reference estimates the renal clearance of fluoride ions from sodium fluoridated water at 35–45 mL/min.⁴

Adverse Effects

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Toxicity

The oral LD50 of sodium fluoride is 44 mg/kg in mice and 31 mg/kg in rats. The oral LD50 of sodium fluoride in rabbits is 200 mg/kg.¹⁵

Overdose information

The ingestion of toothpaste is the major cause of sodium fluoride overdose. This is followed by sodium fluoride supplements and mouth rinses. Most causes of sodium fluoride toxicity have been observed in children under the age of 6 years old.⁵ The manifestations of a sodium fluoride overdose may include gastrointestinal disturbance, abdominal pain, alterations in taste, seizures, salivation, bradycardia, tachycardia, headache, tremor, and shallow breathing.¹⁴ Gastrointestinal bleeding may also occur in addition to a sensation of burning in the mouth.¹² Hypotension, bronchospasm, fixed mydriasis, and elevated potassium can also occur which, in turn, may lead to arrhythmias and cardiac arrest.⁵

Management

If a dose greater than 5 mg fluoride per kilogram of body weight (2.3 mg fluoride per pound of body weight) has been taken, it is advisable to induce vomiting. Administer calcium in an oral, soluble form (for example, 5% calcium gluconate, a solution of calcium lactate, or milk). The patient should seek immediate medical attention. If a sodium fluoride ingestion of 15 mg fluoride/kg of body weight or more occurs (i.e. higher than 6.9 mg fluoride per pound), immediately induce vomiting, provide supportive care, and admit the patient to the hospital for observation.¹²

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Abacavir	Abacavir may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
Aceclofenac	Aceclofenac may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
Acemetacin	Acemetacin may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
Acetaminophen	Acetaminophen may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
Acetazolamide	Acetazolamide may increase the excretion rate of Sodium fluoride which could result in a lower serum level and potentially a reduction in efficacy.

Food Interactions

Avoid milk and dairy products. Do no take this drug within 1 hour of consuming dairy products.

Products

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Fluoride ion	ionic	Q80VPU408O	16984-48-8	KRHYYFGTRYWZRS-UHFFFAOYSA-M
Sodium cation	ionic	LYR4M0NH37	17341-25-2	FKNQFGJONOIPTF-UHFFFAOYSA-N

Product Images

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
60 Second Fluoride Gel	Gel	5.6 g/454g	Dental	Darby Dental Supply, LLC	2019-08-01	Not applicable
60 Second Fluoride Gel	Gel	5.6 g/454g	Dental	Darby Dental Supply, LLC	2019-08-01	Not applicable
60 Second Fluoride Gel	Gel	5.6 g/454g	Dental	Darby Dental Supply, LLC	2019-08-01	Not applicable
60 Second Fluoride Gel	Gel	5.6 g/454g	Dental	Darby Dental Supply, LLC	2019-08-01	Not applicable
60 Second Fluoride Gel	Gel	5.6 g/454g	Dental	Darby Dental Supply, LLC	2019-08-01	Not applicable

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
0.2% Sodium Fluoride Weekly Oral Rinse	Solution	0.2 %	Dental	Pdt Image Inc. Dba Pro Dentec Canada	1995-12-31	2009-06-15
1.1% Neutral Sodium Fluoride Topical Gel	Gel	1.1 %	Dental	Pdt Image Inc. Dba Pro Dentec Canada	1995-12-31	2009-06-15
2080 K Ginger Mint	Paste	0.12 g/120g	Dental	Aekyung Industrial Co., Ltd.	2016-07-07	Not applicable
2080 K Herbal Mint	Paste	0.12 g/120g	Dental	Aekyung Industrial Co., Ltd.	2016-07-07	Not applicable
2080 K Original	Paste	0.12 g/120g	Dental	Aekyung Industrial Co., Ltd.	2016-07-07	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
365 Whole Foods Market Anticavity/Antigingivitis Mouthwash	Sodium fluoride (0.1 mg/1mL) + Eucalyptol (0.92 mg/1mL) + Menthol (0.42 mg/1mL) + Methyl salicylate (0.6 mg/1mL) + Thymol (0.64 mg/1mL)	Mouthwash	Dental	Whole Foods Market, Inc.	2022-01-31	Not applicable
4 Pack	Sodium fluoride (2.4 mg/1g) + Sodium fluoride (2.4 mg/1g) + Potassium nitrate (50 mg/1g) + Potassium nitrate (50 mg/1g)	Kit; Paste	Dental	Smiletwice, Inc.	2018-09-14	Not applicable
4 Pack	Sodium fluoride (2.4 mg/1g) + Sodium fluoride (2.4 mg/1g) + Potassium nitrate (50 mg/1g) + Potassium nitrate (50 mg/1g)	Kit; Paste	Dental	Smiletwice, Inc.	2018-09-14	Not applicable
Acidulated Phosphate Fluoride Oral Solution	Sodium fluoride (.65 %) + Hydrogen fluoride (.017 %)	Solution	Dental	Pdt Image Inc. Dba Pro Dentec Canada	1995-12-31	1999-07-30
ADDAMEL INFUSION N	Sodium fluoride (2.1 mg) + Chromic chloride hexahydrate (53.3 mcg) + Cupric chloride dihydrate (3.4 mg) + Ferric chloride hexahydrate (5.4 mg) + Manganese chloride tetrahydrate (990 mcg) + Potassium Iodide (166 mcg) + Sodium selenite pentahydrate (105 mcg) + Sodium molybdate dihydrate (48.5 mcg) + Zinc chloride (13.6 mg)	Solution, concentrate	Intravenous	FRESENIUS KABI COLOMBIA S.A.S.	2006-11-10	2009-05-08

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
60 Second Fluoride Gel	Sodium fluoride (5.6 g/454g)	Gel	Dental	Darby Dental Supply, LLC	2019-08-01	Not applicable
60 Second Fluoride Gel	Sodium fluoride (5.6 g/454g)	Gel	Dental	Darby Dental Supply, LLC	2019-08-01	Not applicable
60 Second Fluoride Gel	Sodium fluoride (5.6 g/454g)	Gel	Dental	Darby Dental Supply, LLC	2019-08-01	Not applicable
60 Second Fluoride Gel	Sodium fluoride (5.6 g/454g)	Gel	Dental	Darby Dental Supply, LLC	2019-08-01	Not applicable
60 Second Fluoride Gel	Sodium fluoride (5.6 g/454g)	Gel	Dental	Darby Dental Supply, LLC	2019-08-01	Not applicable

Chemical Identifiers

UNII: 8ZYQ1474W7
CAS number: 7681-49-4
InChI Key: PUZPDOWCWNUUKD-UHFFFAOYSA-M
InChI: InChI=1S/FH.Na/h1H;/q;+1/p-1
IUPAC Name: sodium fluoride
SMILES: [F-].[Na+]

References

General References

Kanduti D, Sterbenk P, Artnik B: FLUORIDE: A REVIEW OF USE AND EFFECTS ON HEALTH. Mater Sociomed. 2016 Apr;28(2):133-7. doi: 10.5455/msm.2016.28.133-137. Epub 2016 Mar 25. [Article]
Peckham S, Awofeso N: Water fluoridation: a critical review of the physiological effects of ingested fluoride as a public health intervention. ScientificWorldJournal. 2014 Feb 26;2014:293019. doi: 10.1155/2014/293019. eCollection 2014. [Article]
Ekstrand J, Spak CJ: Fluoride pharmacokinetics: its implications in the fluoride treatment of osteoporosis. J Bone Miner Res. 1990 Mar;5 Suppl 1:S53-61. doi: 10.1002/jbmr.5650051380. [Article]
Whitford GM, Sampaio FC, Pinto CS, Maria AG, Cardoso VE, Buzalaf MA: Pharmacokinetics of ingested fluoride: lack of effect of chemical compound. Arch Oral Biol. 2008 Nov;53(11):1037-41. doi: 10.1016/j.archoralbio.2008.04.001. Epub 2008 Jun 2. [Article]
Ullah R, Zafar MS, Shahani N: Potential fluoride toxicity from oral medicaments: A review. Iran J Basic Med Sci. 2017 Aug;20(8):841-848. doi: 10.22038/IJBMS.2017.9104. [Article]
Medjedovic E, Medjedovic S, Deljo D, Sukalo A: IMPACT OF FLUORIDE ON DENTAL HEALTH QUALITY. Mater Sociomed. 2015 Dec;27(6):395-8. doi: 10.5455/msm.2015.27.395-398. [Article]
Buzalaf MAR, Pessan JP, Honorio HM, Ten Cate JM: Mechanisms of action of fluoride for caries control. Monogr Oral Sci. 2011;22:97-114. doi: 10.1159/000325151. Epub 2011 Jun 23. [Article]
DenBesten P, Li W: Chronic fluoride toxicity: dental fluorosis. Monogr Oral Sci. 2011;22:81-96. doi: 10.1159/000327028. Epub 2011 Jun 23. [Article]
Authors unspecified: The use of fluoride in infants and children. Paediatr Child Health. 2002 Oct;7(8):569-82. doi: 10.1093/pch/7.8.569. [Article]
Pandit S, Kim JE, Jung KH, Chang KW, Jeon JG: Effect of sodium fluoride on the virulence factors and composition of Streptococcus mutans biofilms. Arch Oral Biol. 2011 Jul;56(7):643-9. doi: 10.1016/j.archoralbio.2010.12.012. Epub 2011 Jan 15. [Article]
MSDS, sodium fluoride [Link]
Daily med: Sodium fluoride tablet, chewable [Link]
Sodium fluoride F-18 injection, DailyMed [Link]
Medline NIH: Fluoride overdose information [Link]
MSDS, sodium fluoride, Fisher Scientific [Link]
What happens to sodium fluoride in your body? DG Health and Consumer Protection [Link]
FDA Approved Drug Products: Apadaz (benzhydrocodone and acetaminophen) tablets [Link]
Fluoride therapy APPD [Link]
ADA guidelines on fluoride use [Link]
Sodium fluoride, science direct [Link]

External Links

Human Metabolome Database: HMDB0303552
KEGG Compound: C08142
PubChem Compound: 5235
PubChem Substance: 310265207
ChemSpider: 5045
BindingDB: 50209223
RxNav: 9873
ChEBI: 28741
ChEMBL: CHEMBL1528
PharmGKB: PA451388
Wikipedia: Sodium_fluoride

Clinical Trials

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Phase	Status	Purpose	Conditions	Count	Start Date	Why Stopped	100+ additional columns
Unlock 175K+ rows when you subscribe.View sample data
Not Available	Active Not Recruiting	Not Available	Arrested Dental Caries / Caries; Initial / Cavitated Caries / Dental Caries in Children / Dental Decay	1	somestatus	stop reason	just information to hide
Not Available	Completed	Not Available	Caries	1	somestatus	stop reason	just information to hide
Not Available	Completed	Not Available	Dental Caries in Children	1	somestatus	stop reason	just information to hide
Not Available	Completed	Not Available	Dental Plaque Imaging Methods	1	somestatus	stop reason	just information to hide
Not Available	Completed	Not Available	Dentin Sensitivity	1	somestatus	stop reason	just information to hide

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Solution	Dental	0.2 %
Gel	Dental	1.1 %
Paste	Dental	0.12 g/120g
Mouthwash	Dental	1.1 mg/1
Tablet	Dental	1.1 mg/1
Gel, dentifrice	Dental	1.69 g/100g
Gel	Buccal; Dental; Topical	12.3 mg/1g
Gel	Buccal; Dental; Topical	27.73 mg/1g
Gel	Dental	12.3 mg/1g
Gel, dentifrice	Oral	5 mg/1g
Liquid	Dental	0.02522 g/1mL
Gel, dentifrice	Oral	11 mg/1g
Solution	Dental
Rinse	Topical	0.5 mg/1mL
Mouthwash	Oral	0.09 mg/1mL
Liquid	Oral	0.05 %
Paste	Topical	1.4 mg/1g
Paste, dentifrice	Topical	1.4 mg/1g
Mouthwash	Topical	0.2 mg/1mL
Rinse	Topical	0.09 mg/1mL
Rinse	Topical	0.2 mg/1mL
Mouthwash	Topical	0.09 mg/1mL
Injection	Intravenous	5.33 mcg/ml
Injection, solution	Intravenous drip
Solution	Intravenous	5.33 mcg/ml
Solution	Intravenous
Paste, dentifrice	Dental	2.4 mg/1g
Kit; paste, dentifrice	Dental	1.5 mg/1g
Mouthwash	Oral	10.41 mg/1mL
Liquid	Oral	0.1 mg/1mL
Liquid	Oral	0.219 mg/1mL
Liquid	Oral	219 mg/1mL
Gel, dentifrice	Dental	2.5 mg/1g
Paste, dentifrice	Dental	0.22 g/100g
Gel, dentifrice	Oral	0.187 g/85g
Paste	Dental	2.2 mg/1g
Paste, dentifrice	Topical	0.1 g/100g
Powder	Dental	0.1 g/100g
Spray	Oral	0.007 mg/35mL
Liquid	Topical	0.005 g/10mL
Mouthwash	Oral	.0221 mL/100L
Mouthwash	Oral	0.02 kg/100L
Mouthwash	Oral	1 mg/1mL
Rinse	Oral	.2 mg/1mL
Rinse	Oral	0.02 mg/1mL
Rinse	Oral	0.05 kg/100L
Rinse	Oral	0.5 mg/1mL
Mouthwash	Oral	.0221 kg/100L
Mouthwash	Oral	.05 kg/100L
Mouthwash	Oral	0.05 kg/100L
Mouthwash	Oral	0.2 mg/1mL
Rinse	Dental	0.46277 mg/1mL
Mouthwash	Oral	10.33 mg/1mL
Paste	Dental	1.15 mg/1g
Paste	Dental	1.4 mg/1g
Paste	Dental	1.13 mg/1g
Paste, dentifrice	Buccal	0.22 %
Paste, dentifrice	Dental	.221 %
Gel	Dental	1.5 mg/1g
Paste	Dental	1.1 mg/1g
Paste	Dental	1.10 mg/1g
Paste	Dental	1.5 mg/1g
Liquid	Dental	0.001 mg/1mL
Gel; paste, dentifrice	Dental	0.243 %
Paste	Dental	.243 %
Gel	Dental	0.243 %
Paste	Topical	0.2 g/100g
Liquid	Oral	0.24 g/100mL
Liquid	Dental	2 g/1L
Liquid	Dental	0.05 g/100mL
Liquid	Dental
Gel, dentifrice	Dental	0.243 g/100g
Paste, dentifrice	Dental	0.53 mg/1g
Gel, dentifrice	Dental	0.25 g/100g
Pellet	Oral	0.00066 mg/1.1mg
Tablet	Oral	9.38 mg/853mg
Paste	Dental	0.122 g/100mL
Kit	Dental; Oral
Gel, dentifrice	Dental	0.1 g/100g
Mouthwash	Oral	0.0225 g/100g
Gel	Dental	4.086 g/454g
Paste, dentifrice	Dental	1.3 mg/1g
Kit	Dental; Topical
Suspension	Oral
Mouthwash	Oral	0.905 mg/1mL
Paste, dentifrice	Dental	2.35 mg/1g
Mouthwash	Buccal
Liquid; mouthwash	Buccal
Gel, dentifrice	Dental; Oral	0.22 g/100g
Tablet, chewable	Oral	1.2 mg/1
Paste, dentifrice	Oral	0.75 g/150g
Paste, dentifrice	Oral	0.950 mg/1g
Gel	Dental	0.27 g/113.4g
Gel	Dental	0.54 g/226.8g
Gel, dentifrice	Dental	243 mg/1g
Gel; paste, dentifrice	Dental	0.23 %
Paste, dentifrice	Dental	.23 %
Paste, dentifrice	Oral	0.21 g/100g
Paste, dentifrice	Dental	0.21 g/100g
Paste, dentifrice	Oral	0.916 mg/1g
Rinse	Oral	0.05 g/100mL
Rinse	Dental	2.1 mg/10mL
Paste, dentifrice	Dental	0.243 %
Paste, dentifrice	Dental	.243 %
Gel	Buccal; Oral
Paste, dentifrice	Dental	0.24 mg/1g
Gel, dentifrice	Dental	2.4 mg/1g
Rinse	Dental	0.1 mg/1mL
Gel, dentifrice	Dental	1.1 mg/1g
Gel, dentifrice	Dental	24 mg/1g
Paste, dentifrice	Dental	1.4 mg/1g
Paste, dentifrice	Dental	1 mg/1g
Rinse	Dental	2 mg/10mL
Gel, dentifrice; kit	Dental
Paste, dentifrice	Dental	3.281 mg / mL
Paste, dentifrice	Dental	1.1 mg/1g
Gel, dentifrice	Dental
Paste, dentifrice	Dental
Paste, dentifrice	Dental	0.32 mg/1mL
Rinse	Oral	0.0219 g/1mL
Paste, dentifrice	Oral	5 mg/1g
Powder, dentifrice	Dental	1.88 mg/1g
Kit; paste, dentifrice	Dental	1.6 mg/1g
Kit	Dental	1.5 mg/1g
Paste, dentifrice	Dental	1.45 g/100mL
Paste, dentifrice	Dental	2.43 mg/100mL
Paste, dentifrice	Oral	243 mg/1g
Rinse	Oral	0.1 mg/10mL
Rinse	Oral	2.2 mg/10mL
Rinse	Oral	0.05 mg/1mL
Paste, dentifrice	Dental	1.6 mg/1g
Rinse	Oral	0.1 mg/1mL
Rinse	Oral	0.2 mg/10mL
Gel, dentifrice	Topical	1.5 mg/1g
Rinse	Dental	226 ug/1mL
Gel, dentifrice	Dental	1100 ug/1g
Gel, dentifrice	Dental	5000 ug/1g
Mouthwash	Oral
Liquid	Oral	0.05 g/100g
Gel	Dental	0.0272 g/1mL
Aerosol, foam	Dental	0.0272 g/1g
Paste	Dental	39.9 g/181.4g
Paste	Dental	0.76 g/100g
Paste, dentifrice	Oral	0.11 g/100g
Kit	Dental	1.6 mg/1g
Kit; paste	Dental	1.5 mg/1g
Tablet, chewable	Oral	1.1 mg/1
Cream	Oral	1.1 g/100g
Gel, dentifrice	Oral	1.1 g/100g
Gel	Dental; Oral	2 g
Gel	Oral	1.1 g/100g
Rinse	Oral	0.05 mL/100mL
Paste, dentifrice	Dental	0.1 g/100g
Gel	Dental	0.221 %
Mouthwash	Dental	0.02 mg/100mL
Tape	Dental	.15 mg / 45 cm
Paste, dentifrice	Dental	243 mg/1g
Paste, dentifrice	Dental	0.239 g/100g
Paste, dentifrice	Dental	0.09639 g/76.5g
Tablet	Dental	1.10037 g/1
Liquid	Dental	0.023 %
Liquid	Dental	0.02 g/1mL
Aerosol, foam	Dental
Gel	Dental	0.011 mg/1mL
Gel	Dental	0.011 g/1g
Rinse	Dental	0.02 g/1mL
Paste, dentifrice	Dental; Oral	1.1 mg/1g
Gel, dentifrice	Dental	0.22 g/1000mL
Gel, dentifrice	Dental	0.22 g/100mL
Liquid	Dental	0.02 g/100mL
Paste	Dental	100 mg/100g
Paste	Dental	24 mg/100mg
Gel, dentifrice	Oral	1.1 mg/1g
Paste	Dental	0.11 g/100g
Paste, dentifrice	Topical	0.001 g/0.7g
Liquid	Dental	0.74 g/100mL
Gel	Dental; Oral
Liquid	Topical	0.05 mg/250mL
Liquid	Topical	0.15 mg/750mL
Liquid	Topical	0.016 mg/80mL
Tablet, orally disintegrating	Dental	2 mg/1g
Paste	Dental	0.243 g/100g
Paste	Dental	0.15 g/100g
Liquid	Oral	0.15 g/300mL
Liquid	Dental	2.26 %
Suspension	Oral
Liquid	Dental	50 mg/ml
Gel, dentifrice	Dental	.24 g/100g
Paste, dentifrice	Dental	0.16 g/100g
Paste, dentifrice	Dental	199 mg/75mL
Paste, dentifrice	Dental	110 mg/75mL
Paste, dentifrice	Dental	320 mg/75mL
Solution	Buccal; Oral
Solution	Buccal; Oral	50 mg
Tablet	Oral	0.55 mg/1
Tablet	Oral	1.1 mg/1
Tablet	Oral	2.2 mg/1
Liquid	Oral	0.021 g/1mL
Paste, dentifrice	Dental	0.243 g/100g
Paste, dentifrice	Topical	1.08 mg/1g
Rinse	Oral	0.225 mg/1mL
Paste	Topical
Aerosol, foam	Dental	1.5 mg/1mL
Rinse	Dental	.5 mg/1mL
Paste, dentifrice	Dental	2.43 mg/1mL
Liquid	Dental	0.2 mg/1mL
Aerosol	Dental	1.23 %
Aerosol, foam	Dental	1.732 g/100g
Gel	Dental	5 mg/1mL
Tablet
Tablet
Solution / drops	Oral	5.56 mg/1mL
Solution	Oral	0.55 mg/0.6mL
Tablet	Dental	0.6552 mg/1
Tablet, chewable	Dental	0.00145 1/1
Liquid	Oral	2.5 mg/1mL
Mouthwash	Oral	0.05 g/100mL
Solution	Oral	11 mg/1g
Paste, dentifrice	Dental	5 mg/1g
Paste, dentifrice	Dental	0.011 g/1g
Solution / drops	Oral	200 mg / 28.4 mL
Paste, dentifrice	Topical	1.1 g/100g
Tablet, chewable	Oral	1 mg/1
Liquid	Oral	200 mg / 28.4 mL
Liquid	Oral	.05 %
Tablet, delayed release	Oral	20 mg
Solution	Topical
Solution / drops	Oral	2.21 mg / .2 mL
Liquid	Oral	2.21 mg/.2mL
Gel	Topical	1.1 g/100g
Paste, dentifrice	Dental	0.65 mg/1g
Paste	Dental	22 mg/1g
Gel, dentifrice	Dental	2.43 mg/1g
Gel, dentifrice	Dental	2.2 mg/1g
Gel, dentifrice	Dental	2 g/100g
Gel	Dental; Oral	0.34 g
Liquid	Dental; Topical	1.23 %
Aerosol, foam	Dental	1.125 g/125g
Aerosol, foam	Dental; Oral; Topical	2.5 g/125g
Gel, dentifrice	Dental	10.241 g/100g
Paste, dentifrice	Dental	.22 %
Paste, dentifrice	Dental	2.1 mg/1g
Paste, dentifrice	Topical	2.1 mg/1g
Paste	Topical	1.23 %
Cream	Topical
Rinse	Dental; Topical	0.5 mg/1mL
Paste	Oral
Mouthwash	Dental	0.08 g/100mL
Paste, dentifrice	Dental; Oral	2.4 mg/1g
Paste, dentifrice	Oral	0.24 g/100g
Paste, dentifrice	Dental	0.243 mg/100g
Paste	Dental	2.5 mg/1g
Mouthwash	Dental	20 mg/100000mL
Liquid	Topical	0.5 %
Paste, dentifrice	Dental	1.5 mg/1g
Liquid	Oral	0.0022 g/11mL
Aerosol	Dental	1 %
Cream	Oral	0.62 %
Injection, solution	Intravenous	2 GBq/ml
Paste, dentifrice	Oral
Gel	Dental	.24 %
Gel	Dental; Oral	10.241 g/490g
Gel	Dental; Oral	6.027 g/490g
Gel	Dental; Oral; Topical	6.027 g/490g
Aerosol, foam	Dental; Oral; Topical	1.5498 g/126g
Gel	Dental; Oral	4.41 g/490g
Gel	Dental; Oral; Topical	4.41 g/490g
Liquid	Dental; Oral	38 g/1L
Gel	Oral	0.24 g/100g
Gel, dentifrice	Topical	0.243 g/100g
Gel, dentifrice	Topical	1.1 g/100g
Gel, dentifrice	Topical	1.11 g/100g
Gel	Dental	1.23 %
Liquid	Oral	1.95 mg / mL
Tablet	Oral	1 mg / tab
Gel	Dental	0.5 %
Tablet, chewable	Dental	0.37 mg/440mg
Paste, dentifrice	Dental	0.265 g/100g
Rinse	Oral	.02 mg/1mL
Paste, dentifrice	Dental	0.239 g / 100 g
Paste	Oral	0.02 g/100g
Rinse	Oral	0.02 g/100mL
Kit	Dental	2.43 mg/1g
Kit; paste, dentifrice	Dental	2.43 mg/1g
Paste, dentifrice	Topical	0.2592 g/108g
Paste	Topical	0.2592 g/108g
Aerosol, foam	Dental	12.3 mg/1g
Aerosol, foam	Dental	27.2 mg/1g
Aerosol, foam	Dental	0.9 mg/1g
Gel	Dental	12.3 mg/1mL
Aerosol, foam	Dental	1.23 mg/1g
Aerosol, foam	Dental	1.23 g/1g
Paste	Dental	2.43 mg/1g
Paste, dentifrice	Oral	2.5 mg/1g
Mouthwash	Oral	0.1 mg/1mL
Mouthwash	Dental	0.1 mg/1mL
Mouthwash	Oral	0.221 g/1mL
Solution	Buccal; Oral	22.1 mg
Solution	Buccal; Oral	0.05 g
Tablet, chewable	Oral	0.25 mg/1
Tablet, chewable	Oral	0.5 mg/1
Tablet, chewable	Oral	1.0 mg/1
Paste, dentifrice	Oral	0.0015 g/1
Kit; paste	Dental
Paste, dentifrice	Buccal	0.25 g/96g
Mouthwash	Dental; Oral
Paste, dentifrice	Dental; Oral	2.2 mg/1mL
Gel, dentifrice	Oral	0.1 g/100g
Gel	Dental	2.2 mg/1g
Paste, dentifrice	Dental	2.2 mg/1g
Paste	Dental	0.198 g/90g
Paste	Dental	22 g/100g
Paste, dentifrice	Dental	22 g/100g
Gel, dentifrice	Dental	0.10 g/100g
Gel, dentifrice	Dental	0.15 g/100g
Kit	Dental
Paste	Oral	0.2938 g/113g
Paste, dentifrice	Dental	0.11 g/100g
Paste, dentifrice	Dental	0.15 g/100g
Paste, dentifrice	Dental	2 g/0.2g
Paste, dentifrice	Dental	0.2 g/100g
Paste	Topical	0.24 g/100g
Paste	Oral	2.2 mg/1g
Liquid	Oral	0.20 mg/1mL
Solution	Oral
Tablet	Oral
Tablet, chewable	Oral
Powder	Dental	1 g/1g
Solution	Dental	20 mg/10mL
Solution	Dental	2 mg/1mL
Paste, dentifrice	Dental	0.0015 g/1g
Mouthwash	Dental	0.2 mg/1mL
Gel	Oral	1.428 g/120g
Gel	Dental	11.28 mg/1g
Gel	Dental	7 mg/1g
Gel, dentifrice	Dental	1.1 g/100g
Liquid	Dental; Oral	2 %
Liquid	Topical	2 mL/100mL
Gel	Dental	0.02 g/1mL
Rinse	Oral	20 mg/1mL
Rinse	Oral	9 mg/10mL
Paste	Oral	1.1 g/112g
Paste, dentifrice	Oral	1.1 g/112g
Rinse	Dental	2 g/100g
Gum, chewing; kit; paste	Dental; Oral
Aerosol, foam	Dental	27.3 mg/1g
Gel	Topical
Gel	Dental	20 mg/1g
Rinse	Dental	20 mg/1g
Gel	Dental	25.9 mg/1g
Gel	Topical	2 %
Capsule, liquid filled	Oral
Solution	Intravenous	0.053 mg/10ml
Paste, dentifrice	Oral	0.22 g/1001
Rinse	Oral	0.0154 g/770mL
Liquid	Oral	0.06 mg/300mL
Paste, dentifrice	Dental	1.13 mg/1g
Paste	Dental	0.1 g/100g
Gel, dentifrice	Dental	6 mg/1g
Paste	Buccal
Mouthwash	Oral	.1 mg/1mL
Mouthwash	Buccal; Topical
Solution	Oral	12.3 mg/1g
Solution	Oral	0.5 mg/1g
Paste, dentifrice	Dental	.14 g/118g
Mouthwash	Oral	.2418 g/474mL
Paste, dentifrice	Topical	0.11 g/100g
Liquid	Buccal; Topical	0.05 %
Liquid	Dental	500 ug/1mL
Mouthwash	Dental	2 mg/1mL
Aerosol	Dental
Aerosol	Dental	10 mg/1g
Aerosol	Dental	9 mg/1g
Gel	Dental	11 mg/1g
Cream; paste, dentifrice	Topical
Solution	Oral	0.05 g
Gel, dentifrice	Oral	.15 g/100g
Gel, dentifrice	Oral	0.15 g/100g
Paste, dentifrice	Oral	0.15 g/100g
Mouthwash	Oral	0.15 g/100g
Rinse	Dental
Gel, dentifrice	Oral	4.4 mg/10mL
Liquid	Dental; Topical
Rinse	Oral	0.199 mg/1mL
Tablet, delayed release	Oral
Paste, dentifrice	Dental	0.22 %
Liquid	Topical
Aerosol, foam	Dental	2.5 g/125g
Gel	Dental; Topical	11.1 mg/1mL
Gel	Dental; Topical	27.2 mg/1mL
Rinse	Dental; Topical	27.2 mg/1mL
Liquid	Topical	27.2 mg/1mg
Gel	Topical	20 mg/1g
Gel	Dental; Topical	20 mg/1mL
Aerosol, foam	Topical	0.0272 g/1g
Gel	Topical	11 mg/1mg
Aerosol, foam	Topical	.0272 mg/1g
Aerosol, foam	Topical	20.0 mg/1mg
Gel	Topical	20.0 mg/1mg
Gel	Topical	20 mg/1mg
Rinse	Dental; Topical	20 mg/1mL
Rinse	Topical	2 mg/1mL
Rinse	Dental; Topical	2 mg/1mL
Liquid	Topical	20.0 mg/1mg
Rinse	Dental; Topical	2 mg/1g
Rinse	Topical	2 mg/1g
Gel	Topical	27.2 mg/1mg
Gel	Topical	.02 mg/1mL
Aerosol, foam	Dental; Topical	0.0272 g/1g
Aerosol, foam	Dental; Topical	0.02 g/1g
Mouthwash	Oral	.2 %
Liquid	Dental	.227 mg / mL
Paste	Dental	0.24 g/100g
Injection, solution	Intravenous
Injection, solution, concentrate	Intravenous; Parenteral
Injection, solution, concentrate	Parenteral
Solution, concentrate	Intravenous
Injection	Intravenous
Paste, dentifrice	Oral	0.243 g/100g
Gel	Oral	0.5 %
Mouthwash	Dental	1.24 %
Gel	Dental	2 %
Paste, dentifrice	Dental	2.72 %
Paste, dentifrice	Dental	0.24 mg/100mL
Solution	Dental	2 %
Gel	Buccal; Dental; Topical	9.05 mg/1g
Disc	Topical
Disc	Topical	0.055 mg/1
Rinse	Dental	4.42 mg/10mL
Paste, dentifrice	Oral	0.308 g/140g
Paste, dentifrice	Oral	0.374 g/170g
Paste, dentifrice	Dental; Oral	0.4 mg/1g
Paste	Dental	14 mg/1g
Paste	Dental	24 mg/1g
Paste	Dental	130 mg/100g
Paste, dentifrice	Dental	0.14 g/100g
Suspension / drops	Oral
Solution / drops	Oral
Gel, dentifrice	Dental	0.24 g/100g
Gel, dentifrice	Dental	11 mg/1g
Gel, dentifrice	Dental	13.4 mg/1mL
Paste, dentifrice	Dental	6 mg/1mL
Gel, dentifrice	Dental	6.1 mg/1mL
Paste, dentifrice	Dental	11 mg/1g
Mouthwash	Dental	0.9 mg/1mL
Gel	Dental	2.1 mg/1g
Gel	Oral	0.044 mL/1mL
Gel	Oral	0.2 mg/1mL
Gel	Oral	4.3 g/1g
Gel	Oral	4.3 mg/1g
Gel	Oral	44 mg/1mL
Gel	Oral	5 mg/1g
Rinse	Oral	0.9 mg/1mL
Rinse	Oral	0.946 mL/1mL
Rinse	Oral	9 mg/1mL
Liquid	Buccal	0.5 %
Liquid	Dental; Oral	0.9 %
Liquid	Dental; Oral
Paste	Dental	0.23 g/100g
Mouthwash	Oral	.2 mg/1mL
Paste, dentifrice	Oral	1.1 g/100g
Liquid	Oral	0.02 g/100mL
Gel, dentifrice	Dental	0.07 g/28.35g
Aerosol, foam	Dental	1.5375 g/125g
Paste, dentifrice	Dental	0.23 g/100g
Mouthwash	Dental	0.05 g/100mL
Paste	Dental	0.22 g/100g
Gel	Dental	0.24 %
Tape	Dental	0.15 mg / 45 cm
Paste, dentifrice	Oral	2.43 mg/1g
Paste, dentifrice	Oral	24.3 mg/1g
Paste, dentifrice	Oral	1.5 mg/1g
Gel, dentifrice	Dental	0.22 g/100g
Paste, dentifrice	Dental	0.242 g/110g
Paste	Dental	0.4 g/100g
Aerosol, foam	Dental; Oral; Topical	0.0123 g/1mL
Gel	Dental; Oral; Topical	0.02 g/1mL
Mouthwash	Dental	0.11 g/100mL
Gel	Dental
Paste, dentifrice	Topical
Paste	Oral	1.5 mg/1g
Mouthwash	Oral	0.2 mg/1L
Cream	Dental	5 mg/1g
Paste, dentifrice	Oral	0.0905 g/100g
Film	Dental	20 mg/1
Gel	Dental	10.241 g/100g
Gel	Dental	4.41 g/100g
Paste	Dental	2.4 mg/100g
Liquid	Dental	0.05 mg/100g
Paste, dentifrice	Topical	2.4 mg/1g
Paste, dentifrice	Dental	0.0024 g/1g
Liquid	Oral	0.5 mg/1mL
Liquid	Oral	0.2 mg/1mL
Paste, dentifrice	Oral	2.4 mg/1g
Rinse	Oral	0.2 mg/1mL
Paste, dentifrice	Dental	5 mg/1mL
Cream	Oral	0.22 g/100g
Solution	Oral	0.2 mg/1mL
Solution / drops	Oral	0.5 mg/1mL
Gel	Dental	5 mg/1g
Paste	Dental	6 mg/1mL
Tablet	Oral	0.25 mg/1
Tablet	Oral	0.5 mg/1
Tablet	Oral	1 mg/1
Liquid	Oral	6.9 mg / mL
Tablet	Oral	2.21 mg
Liquid	Dental	.25 mg / drop
Liquid	Topical	0.02 g/100mL
Mouthwash	Dental	0.02 g/100mL
Gel	Dental	0.597 g/120g
Concentrate	Dental	1702.5 mg/113.5mL
Paste, dentifrice	Dental	0.24 g/100g
Liquid	Oral	0.50 mg/1mL
Kit; liquid; paste	Dental; Oral
Gel; kit; liquid; paste	Dental; Oral
Gel, dentifrice	Dental	1.5 mg/1g
Paste, dentifrice	Dental	0.28 g/113g
Paste, dentifrice	Dental	1.1 g/100g
Paste	Dental	1 mg/1g
Injection, solution, concentrate	Intravenous
Mouthwash	Oral	0.02 g/100mL
Tablet	Oral	0.22 1/1
Gel, dentifrice	Dental	5 mg/1g
Paste, dentifrice	Dental	0.33 g/133g
Paste	Dental	1.23 %
Paste	Dental	0.243 %
Liquid	Topical	0.1 mg/1mL
Paste, dentifrice	Oral	1.25 mg/1mL
Paste, dentifrice	Dental	0.2430 g/100g
Gel, dentifrice	Topical	0.0002 g/251
Rinse	Oral	0.005 mg/10mL
Paste, dentifrice	Oral	0.0024 g/1g
Rinse	Oral	0.0005 g/1g
Gel, dentifrice	Dental	24 mg/10g
Paste, dentifrice	Dental	243 mg/100mL
Tablet	Oral	0.7 mg/1.54mg
Gel, dentifrice	Dental	0.00243 g/1g
Rinse	Dental	0.2 mg/1mL
Gel, dentifrice	Dental	1.4 mg/1g
Paste, dentifrice	Dental	0.00243 g/1g
Tablet	Periodontal	1.54 mg/100g
Paste	Topical	0.06804 g/28g
Powder	Dental	0.24 g/100g
Gel	Dental	5.6 g/454g
Aerosol, foam	Dental	0.02 g/1g
Aerosol, foam	Topical	123 mg/1g
Aerosol	Dental	0.9 %
Liquid	Dental	0.08 g/100mL
Rinse	Dental	0.1 mg/20mL
Injection, solution	Parenteral
Liquid	Oral
Paste, dentifrice	Dental	0.243 mg/1g
Aerosol, foam	Dental	1.23 g/100g
Mouthwash	Oral	0.001 g/10mL
Tablet, chewable	Dental	0.62 mg/1
Tablet, chewable	Dental	0.45 mg/312mg
Tablet, chewable	Dental	0.62 mg/312mg
Paste, dentifrice	Dental	2.43 mg/1g
Paste	Dental
Paste, dentifrice	Dental	0.10 g/100g
Gel, dentifrice	Dental; Oral	11 mg/1g
Paste, dentifrice	Dental	2.0 mg/1g
Kit	Oral
Paste	Dental	2.4 mg/1g
Paste, dentifrice	Topical	1 mg/1g
Paste, dentifrice	Dental	0.243 g/100mL
Mouthwash	Dental
Paste	Topical	0.26244 g/108g
Paste, dentifrice	Dental	0.24 %
Liquid	Buccal; Oral	0.0002 %
Mouthwash	Oral	0.559 mg/1mL
Paste	Oral	0.0028 g/1g
Mouthwash	Oral	0.5 mg/1mL
Aerosol, foam	Dental	2.72 g/100g
Solution / drops	Oral
Solution / drops	Oral	1.14 MG/ML
Tablet		0.25 mg
Tablet		1 mg
Gel
Tablet, chewable	Oral	0.25 mg

Prices

Not Available

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)	Region
US8323683	No	2012-12-04	2028-04-30

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	993	http://www.inchem.org/documents/icsc/icsc/eics0951.htm
boiling point (°C)	1700	http://www.inchem.org/documents/icsc/icsc/eics0951.htm
water solubility	4g/100mL	http://www.inchem.org/documents/icsc/icsc/eics0951.htm
pKa	3.17	http://foodb.ca/compounds/FDB015440

Predicted Properties

Property	Value	Source
logP	0.15	Chemaxon
pKa (Strongest Acidic)	3.17	Chemaxon
Physiological Charge	-1	Chemaxon
Hydrogen Acceptor Count	0	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	0 Å²	Chemaxon
Rotatable Bond Count	0	Chemaxon
Refractivity	0.87 m³·mol^-1	Chemaxon
Polarizability	0.44 Å³	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	Yes	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

Chromatographic Properties

Collision Cross Sections (CCS)

Adduct	CCS Value (Å²)	Source type	Source
[M-H]-	109.705154	predicted	DeepCCS 1.0 (2019)
[M+H]+	111.4721	predicted	DeepCCS 1.0 (2019)
[M+Na]+	118.564766	predicted	DeepCCS 1.0 (2019)

Targets

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Details1. Hydroxyapatite

Kind

Small molecule

Organism

Humans

Pharmacological action

Unknown

References

Buzalaf MAR, Pessan JP, Honorio HM, Ten Cate JM: Mechanisms of action of fluoride for caries control. Monogr Oral Sci. 2011;22:97-114. doi: 10.1159/000325151. Epub 2011 Jun 23. [Article]
Ullah R, Zafar MS, Shahani N: Potential fluoride toxicity from oral medicaments: A review. Iran J Basic Med Sci. 2017 Aug;20(8):841-848. doi: 10.22038/IJBMS.2017.9104. [Article]

Enzymes

Details1. Enolase-phosphatase E1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)
Specific Function: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity
Gene Name: ENOPH1
Uniprot ID: Q9UHY7
Uniprot Name: Enolase-phosphatase E1
Molecular Weight: 28932.44 Da

References

Qin J, Chai G, Brewer JM, Lovelace LL, Lebioda L: Fluoride inhibition of enolase: crystal structure and thermodynamics. Biochemistry. 2006 Jan 24;45(3):793-800. doi: 10.1021/bi051558s. [Article]
Gupta S, Kaur H: Inhibition of Glycolysis for Glucose Estimation in Plasma: Recent Guidelines and their Implications. Indian J Clin Biochem. 2014 Apr;29(2):262-4. doi: 10.1007/s12291-013-0405-1. Epub 2013 Nov 22. [Article]

Details2. Enolase

Kind: Protein
Organism: Streptococcus mutans
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
Specific Function: Magnesium ion binding
Gene Name: eno
Uniprot ID: A0A448RWU9
Uniprot Name: Enolase
Molecular Weight: 46801.075 Da

References

Marsh PD, Bradshaw DJ: The effect of fluoride on the stability of oral bacterial communities in vitro. J Dent Res. 1990 Feb;69 Spec No:668-71; discussion 682-3. doi: 10.1177/00220345900690S129. [Article]
Yasuda K, Hsu T, Gallini CA, Mclver LJ, Schwager E, Shi A, DuLong CR, Schwager RN, Abu-Ali GS, Franzosa EA, Garrett WS, Huttenhower C, Morgan XC: Fluoride Depletes Acidogenic Taxa in Oral but Not Gut Microbial Communities in Mice. mSystems. 2017 Aug 8;2(4). pii: mSystems00047-17. doi: 10.1128/mSystems.00047-17. eCollection 2017 Jul-Aug. [Article]
Guha-Chowdhury N, Clark AG, Sissons CH: Inhibition of purified enolases from oral bacteria by fluoride. Oral Microbiol Immunol. 1997 Apr;12(2):91-7. [Article]
Walter J. Loesche (1996). Medical microbiology (4th ed.). : University of Texas Medical Branch at Galveston.

Details3. Enolase

Kind: Protein
Organism: Lactobacillus casei (strain BL23)
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Catalyzes the reversible conversion of 2-phosphoglycerate (2-PG) into phosphoenolpyruvate (PEP). It is essential for the degradation of carbohydrates via glycolysis.
Specific Function: magnesium ion binding
Gene Name: eno
Uniprot ID: B3WCW7
Uniprot Name: Enolase
Molecular Weight: 47110.665 Da

References

Marsh PD, Bradshaw DJ: The effect of fluoride on the stability of oral bacterial communities in vitro. J Dent Res. 1990 Feb;69 Spec No:668-71; discussion 682-3. doi: 10.1177/00220345900690S129. [Article]
Yasuda K, Hsu T, Gallini CA, Mclver LJ, Schwager E, Shi A, DuLong CR, Schwager RN, Abu-Ali GS, Franzosa EA, Garrett WS, Huttenhower C, Morgan XC: Fluoride Depletes Acidogenic Taxa in Oral but Not Gut Microbial Communities in Mice. mSystems. 2017 Aug 8;2(4). pii: mSystems00047-17. doi: 10.1128/mSystems.00047-17. eCollection 2017 Jul-Aug. [Article]
Walter J. Loesche (1996). Medical microbiology (4th ed.). : University of Texas Medical Branch at Galveston.

Details4. Enolase

Kind: Protein
Organism: Streptococcus sanguinis (strain SK36)
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Catalyzes the reversible conversion of 2-phosphoglycerate (2-PG) into phosphoenolpyruvate (PEP). It is essential for the degradation of carbohydrates via glycolysis.
Specific Function: magnesium ion binding
Gene Name: eno
Uniprot ID: A3CMA7
Uniprot Name: Enolase
Molecular Weight: 47029.465 Da

References

Yasuda K, Hsu T, Gallini CA, Mclver LJ, Schwager E, Shi A, DuLong CR, Schwager RN, Abu-Ali GS, Franzosa EA, Garrett WS, Huttenhower C, Morgan XC: Fluoride Depletes Acidogenic Taxa in Oral but Not Gut Microbial Communities in Mice. mSystems. 2017 Aug 8;2(4). pii: mSystems00047-17. doi: 10.1128/mSystems.00047-17. eCollection 2017 Jul-Aug. [Article]

Details5. Enolase

Kind: Protein
Organism: Streptococcus salivarius
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
Specific Function: Magnesium ion binding
Gene Name: eno
Uniprot ID: A0A1C7C740
Uniprot Name: Enolase
Molecular Weight: 46760.005 Da

References

Yasuda K, Hsu T, Gallini CA, Mclver LJ, Schwager E, Shi A, DuLong CR, Schwager RN, Abu-Ali GS, Franzosa EA, Garrett WS, Huttenhower C, Morgan XC: Fluoride Depletes Acidogenic Taxa in Oral but Not Gut Microbial Communities in Mice. mSystems. 2017 Aug 8;2(4). pii: mSystems00047-17. doi: 10.1128/mSystems.00047-17. eCollection 2017 Jul-Aug. [Article]
Guha-Chowdhury N, Clark AG, Sissons CH: Inhibition of purified enolases from oral bacteria by fluoride. Oral Microbiol Immunol. 1997 Apr;12(2):91-7. [Article]

Drug created at November 17, 2015 18:36 / Updated at October 07, 2024 13:58

Sodium fluoride

Identification

Structure for Sodium fluoride (DB09325)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Clinical Trial & Rare Diseases Add-on Data Package

Pharmacoeconomics

Properties

Spectra

Collision Cross Sections (CCS)

Targets

References

Enzymes

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References