Peroxisomal acyl-coenzyme A oxidase 1

BE0004135ProteinHumansACOX1

Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids (VLCFAs) (PubMed:15060085, PubMed:17458872, PubMed:17603022, PubMed:32169171, PubMed:33234382, PubMed:7876265). It is acted on by 3 drugs in DrugBank.

Gene name
ACOX1
UniProtKB entry
Q15067Swiss-Prot
Cellular location
Peroxisome
Residues / weight
660 residues · 74,423 Da
Also known as
1.3.3.6 · ACOX · AOX · Palmitoyl-CoA oxidase · Peroxisomal fatty acyl-CoA oxidase

Resolves to

Protein
UniProtQ15067UniProt nameACOX1_HUMAN
Gene
HGNCHGNC:119NCBI Gene51GenBank495475GeneCardsACOX1
Pharmacology
KEGGhsa:51
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peroxisomal acyl-coenzyme A oxidase 1, how selective are they, and which programs against it are still in active trials?

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