Ephrin type-A receptor 7

BE0004140ProteinHumansEPHA7

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It is acted on by 2 drugs in DrugBank.

Gene name
EPHA7
UniProtKB entry
Q15375Swiss-Prot
Cellular location
Cell membrane
Residues / weight
998 residues · 112,096 Da
Also known as
2.7.10.1 · EHK-3 · EHK3 · EK11 · EPH homology kinase 3

Resolves to

Protein
UniProtQ15375UniProt nameEPHA7_HUMAN
Gene
HGNCHGNC:3390NCBI Gene2045GenBank551608GeneCardsEPHA7
Pharmacology
IUPHAR/GtoPdb1827KEGGhsa:2045
Structure
PDB2REIPDB3DKOPDB3H8M
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ephrin type-A receptor 7, how selective are they, and which programs against it are still in active trials?

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