Gelsolin

BE0004161ProteinHumansGSN

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It is acted on by 4 drugs in DrugBank.

Gene name: GSN
UniProtKB entry: P06396Swiss-Prot
Cellular location: Cytoplasm, cytoskeleton
Residues / weight: 782 residues · 85,697 Da
Also known as: Actin-depolymerizing factor · ADF · AGEL · Brevin

Resolves to

Protein

UniProtP06396UniProt nameGELS_HUMAN

Gene

HGNCHGNC:4620NCBI Gene2934GenBank736249GeneCardsGSN

Pharmacology

KEGGhsa:2934

Structure

PDB1C0FPDB1C0GPDB1D4X

Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action

32GO termsFunction, process and component, as structured annotations

1Pfam domainDomain architecture mapped to Pfam families and clans

25+ReferencesStructured and connected to the statements they support

Which approved drugs act on Gelsolin, how selective are they, and which programs against it are still in active trials?

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