Beta-lactamase SHV-1

BE0004185ProteinKlebsiella pneumoniaebla

Broad-spectrum beta-lactamase which confers resistance to penicillins, as well as first- and third-generation cephalosporins (PubMed:10639363, PubMed:18955486, PubMed:19351161, PubMed:22908166, PubMed:23145056, PubMed:23252553). It is acted on by 6 drugs in DrugBank.

Gene name
bla
UniProtKB entry
P0AD64Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
286 residues · 31,224 Da
Also known as
3.5.2.6 · blaSHV-1 · PIT-2 · shv1 · Sulfhydryl reagent variable 1

Resolves to

Protein
UniProtP0AD64UniProt nameBLA1_KLEPN
Gene
GenBank151861
Structure
PDB1ONGPDB1Q2PPDB1RCJ
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Beta-lactamase SHV-1, how selective are they, and which programs against it are still in active trials?

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