Tyrosine-protein kinase Mer

BE0004271ProteinHumansMERTK

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. It is acted on by 8 drugs in DrugBank.

Gene name
MERTK
UniProtKB entry
Q12866Swiss-Prot
Cellular location
Cell membrane
Residues / weight
999 residues · 110,248 Da
Also known as
2.7.10.1 · MER · Proto-oncogene c-Mer · Receptor tyrosine kinase MerTK

Resolves to

Protein
UniProtQ12866UniProt nameMERTK_HUMAN
Gene
HGNCHGNC:7027NCBI Gene10461GenBank505665GeneCardsMERTK
Pharmacology
IUPHAR/GtoPdb1837KEGGhsa:10461
Structure
PDB2DBJPDB2P0CPDB3BPR
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase Mer, how selective are they, and which programs against it are still in active trials?

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