Ribosomal protein S6 kinase alpha-1

BE0004274ProteinHumansRPS6KA1

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular... It is acted on by 2 drugs in DrugBank.

Gene name
RPS6KA1
UniProtKB entry
Q15418Swiss-Prot
Cellular location
Nucleus
Residues / weight
735 residues · 82,722 Da
Also known as
2.7.11.1 · 90 kDa ribosomal protein S6 kinase 1 · MAP kinase-activated protein kinase 1a · MAPK-activated protein kinase 1a · MAPKAP kinase 1a

Resolves to

Protein
UniProtQ15418UniProt nameKS6A1_HUMAN
Gene
HGNCHGNC:10430NCBI Gene6195GenBank292457GeneCardsRPS6KA1
Pharmacology
IUPHAR/GtoPdb1527KEGGhsa:6195
Structure
PDB2WNTPDB2Z7QPDB2Z7R
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
15GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
31+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Ribosomal protein S6 kinase alpha-1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In