Elongation factor 2

BE0004281ProteinHumansEEF2

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). It is acted on by 13 drugs in DrugBank.

Gene name
EEF2
UniProtKB entry
P13639Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
858 residues · 95,337 Da
Also known as
3.6.5.- · EF-2 · EF2

Resolves to

Protein
UniProtP13639UniProt nameEF2_HUMAN
Gene
HGNCHGNC:3214NCBI Gene1938GenBank31106GeneCardsEEF2
Pharmacology
KEGGhsa:1938
Structure
PDB4V6XPDB6D9JPDB6Z6M
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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31GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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46+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Elongation factor 2, how selective are they, and which programs against it are still in active trials?

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