Calcium/calmodulin-dependent protein kinase type 1D

BE0004324ProteinHumansCAMK1D

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. It is acted on by 2 drugs in DrugBank.

Gene name
CAMK1D
UniProtKB entry
Q8IU85Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
385 residues · 42,913 Da
Also known as
2.7.11.17 · CaM kinase I delta · CaM kinase ID · CaM-KI delta · CaMKI delta

Resolves to

Protein
UniProtQ8IU85UniProt nameKCC1D_HUMAN
Gene
HGNCHGNC:19341NCBI Gene57118GenBank23491810GeneCardsCAMK1D
Pharmacology
IUPHAR/GtoPdb1953KEGGhsa:57118
Structure
PDB2JC6PDB6QP5PDB6T28
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calcium/calmodulin-dependent protein kinase type 1D, how selective are they, and which programs against it are still in active trials?

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