3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

BE0004327ProteinHumansHIBCH

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. It is acted on by 1 drug in DrugBank.

Gene name
HIBCH
UniProtKB entry
Q6NVY1Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
386 residues · 43,482 Da
Also known as
3-hydroxyisobutyryl-coenzyme A hydrolase · 3.1.2.4 · HIB-CoA hydrolase · HIBYL-CoA-H

Resolves to

Protein
UniProtQ6NVY1UniProt nameHIBCH_HUMAN
Gene
HGNCHGNC:4908NCBI Gene26275GenBank3320120GeneCardsHIBCH
Pharmacology
KEGGhsa:26275
Structure
PDB3BPT
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial, and which indications are they being tested in?

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