[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial

BE0004330ProteinHumansPDK3

Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. It is acted on by 5 drugs in DrugBank.

Gene name
PDK3
UniProtKB entry
Q15120Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
406 residues · 46,938 Da
Also known as
2.7.11.2 · PDHK3 · Pyruvate dehydrogenase kinase isoform 3

Resolves to

Protein
UniProtQ15120UniProt namePDK3_HUMAN
Gene
HGNCHGNC:8811NCBI Gene5165GenBank1088285GeneCardsPDK3
Pharmacology
IUPHAR/GtoPdb2143KEGGhsa:5165
Structure
PDB1Y8NPDB1Y8OPDB1Y8P
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial, how selective are they, and which programs against it are still in active trials?

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