Dehydrocholic acid is a synthetic bile acid that was prepared from the oxidation of cholic acid with chromic acid . It has been used for stimulation of biliary lipid secretion.... The use of dehydrocholic acid in over-the-counter products has been discontinued by Health Canada.
- Mechanism
- Curator reviewed · 3 references
It is proposed that dehydrocholic acid induces choleresis, which is associated with biliary lipid secretion and reduced secretion of endogenous and/or exogenous biliary components. Dehydrocholic acid may decrease bile phospholipid secretion due to a lack of micelle formation by dehydrocholic acid-produced bile. A study suggests that due to enhanced permeability of tight junctions in the canalicular membranes, dehydrocholic acid facilitates direct exchange between bile and plasma.
- Primary indication
- No approved therapeutic indications.Curator reviewed · 1 structured indication
- Formula / weight
- C24H34O5 · 402.531 g/mol (avg)
- First approval
- Canada, 1997
- Also known as
- Decholin · Dehydrocholate
Resolves to
OHXPGWPVLFPUSM-KLRNGDHRSA-NSMILES[H][C@@]1(CC[C@@]2([H])[C@]3([H])C(=O)C[C@]4([H])CC(=O)CC[C@]4(C)[C@@]3([H])CC(=O)[C@]12C)[C@H](C)CCC(O)=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Dehydrocholic acid, and which of those have an active Phase 3 trial?
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