Lactase/phlorizin hydrolase

BE0004338ProteinHumansLCT

Broad specificity glycosidase of the intestinal brush border membrane that hydrolyzes lactose, the main sugar in mammalian milk, to produce D-glucose and D-galactose (PubMed:12594539, PubMed:16400612, PubMed:3929764, PubMed:9762914). It is acted on by 10 drugs in DrugBank.

Gene name
LCT
UniProtKB entry
P09848Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
1,927 residues · 218,585 Da
Also known as
Lactase/glycosylceramidase · LPH

Resolves to

Protein
UniProtP09848UniProt nameLPH_HUMAN
Gene
HGNCHGNC:6530NCBI Gene3938GenBank34400GeneCardsLCT
Pharmacology
KEGGhsa:3938
Drugs

What you can answer from here — as of September 03, 2024

10DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lactase/phlorizin hydrolase, how selective are they, and which programs against it are still in active trials?

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