CREB-binding protein

BE0004367ProteinHumansCREBBP

Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). It is acted on by 6 drugs in DrugBank.

Gene name
CREBBP
UniProtKB entry
Q92793Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
2,442 residues · 265,350 Da
Also known as
CBP · Histone lysine acetyltransferase CREBBP · Protein lactyltransferas CREBBP · Protein-lysine acetyltransferase CREBBP

Resolves to

Protein
UniProtQ92793UniProt nameCBP_HUMAN
Gene
HGNCHGNC:2348NCBI Gene1387GenBank4321116GeneCardsCREBBP
Pharmacology
IUPHAR/GtoPdb2734KEGGhsa:1387
Structure
PDB1JSPPDB1LIQPDB1RDT
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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21GO termsFunction, process and component, as structured annotations
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8Pfam domainsDomain architecture mapped to Pfam families and clans
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67+ReferencesStructured and connected to the statements they support
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Which compounds in development act on CREB-binding protein, and which indications are they being tested in?

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