Iodotyrosine deiodinase 1

BE0004373ProteinHumansIYD

Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:15289438, PubMed:18434651, PubMed:25395621, PubMed:28157283). It is acted on by 2 drugs in DrugBank.

Gene name
IYD
UniProtKB entry
Q6PHW0Swiss-Prot
Cellular location
Cell membrane
Residues / weight
289 residues · 33,359 Da
Also known as
1.21.1.1 · C6orf71 · DEHAL1 · Iodotyrosine dehalogenase 1 · IYD-1

Resolves to

Protein
UniProtQ6PHW0UniProt nameIYD1_HUMAN
Gene
HGNCHGNC:21071NCBI Gene389434GenBank31322698GeneCardsIYD
Pharmacology
KEGGhsa:389434
Structure
PDB4TTBPDB4TTCPDB5YAK
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Iodotyrosine deiodinase 1, how selective are they, and which programs against it are still in active trials?

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