Phloxine

DB13911ApprovedWithdrawnSmall molecule

Phloxine B (commonly known simply as phloxine, also known as D&C RED NO. 28) is a color additive which is used both as an inactive ingredient to provide color to... These tablets allow patients to visualise areas where more brushing and flossing are needed.

Mechanism: Pharmacologically active on Cystic fibrosis transmembrane conductance regulator
Curator reviewed
Primary indication: For use in dental disclosing products, allowing for highlighting of bacterial placques.Curator reviewed · 1 structured indication
Formula / weight: C₂₀H₂Br₄Cl₄Na₂O₅ · 829.63 g/mol (avg)
First approval: Canada, 2013
Also known as: CI Acid Red 92 · Cyanosin · D&C Red No. 28
Code names: C.I. 45410

Resolves to

Compound

UNII767IP0Y5NHCAS18472-87-2ChEMBLCHEMBL61441ChEBI87192

Clinical / RWD

RxNorm1310707

Structure

InChIKeyGVKCHTBDSMQENH-UHFFFAOYSA-LSMILES[Na+].[Na+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C1C=C(Br)C([O-])=C2Br

Targets

P13569CFTRQ6PHW0IYDQ86W56PARG

Transporters

P08183ABCB1

What you can answer from here — as of September 16, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

1Structured indicationCondition, population, route and combination as fields, not prose

2Marketed productsAcross 1 country and 2 labellers

9+ReferencesStructured and connected to the statements they support

Which drugs share a target with Phloxine, and which of those have an active Phase 3 trial?

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