This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Brand Names
- Red-cote
- Generic Name
- Phloxine B
Commonly known or available as Phloxine - DrugBank Accession Number
- DB13911
- Background
Phloxine B (commonly known simply as phloxine, also known as D&C RED NO. 28) is a color additive which is used both as an inactive ingredient to provide color to products, or as a colorant in dental disclosing tablets. These tablets allow patients to visualise areas where more brushing and flossing are needed.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Phloxine B (DB13911)
- Weight
- Average: 829.63
Monoisotopic: 823.518525 - Chemical Formula
- C20H2Br4Cl4Na2O5
- Synonyms
- CI Acid Red 92
- Cyanosin
- D&C Red No. 28
- Disodium 2',4',5',7'-tetrabromo-4,5,6,7-tetrachlorofluorescein
- Phloxine
- External IDs
- C.I. 45410
Pharmacology
- Indication
For use in dental disclosing products, allowing for highlighting of bacterial placques.
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Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Disclose Dry Handle Swab Swab 1.5 % Dental Beutlich L.P. 2000-11-30 2005-06-28 Canada 
Red-cote Tablet 5 mg Dental Sunstar Americas 1995-12-31 Not applicable Canada
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzopyrans
- Sub Class
- 1-benzopyrans
- Direct Parent
- Xanthenes
- Alternative Parents
- 2-halobenzoic acids / 3-halobenzoic acids / 4-halobenzoic acids / Halobenzoic acids / Benzoic acids / 1-carboxy-2-haloaromatic compounds / Benzoyl derivatives / Phenoxides / Chlorobenzenes / Aryl bromides show 14 more
- Substituents
- 1-carboxy-2-haloaromatic compound / 2-halobenzoic acid / 2-halobenzoic acid or derivatives / 3-halobenzoic acid / 3-halobenzoic acid or derivatives / 4-halobenzoic acid / 4-halobenzoic acid or derivatives / Aromatic heteropolycyclic compound / Aryl bromide / Aryl chloride show 32 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- organic sodium salt (CHEBI:87192)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 767IP0Y5NH
- CAS number
- 18472-87-2
- InChI Key
- GVKCHTBDSMQENH-UHFFFAOYSA-L
- InChI
- InChI=1S/C20H4Br4Cl4O5.2Na/c21-5-1-3-7(8-9(20(31)32)13(26)15(28)14(27)12(8)25)4-2-6(22)17(30)11(24)19(4)33-18(3)10(23)16(5)29;;/h1-2,29H,(H,31,32);;/q;2*+1/p-2
- IUPAC Name
- disodium 2,3,4,5-tetrachloro-6-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate
- SMILES
- [Na+].[Na+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C1C=C(Br)C([O-])=C2Br
References
- General References
- Not Available
- External Links
- ChemSpider
- 2006228
- 1310707
- ChEBI
- 87192
- ChEMBL
- CHEMBL61441
- Wikipedia
- Phloxine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Swab Dental 1.5 % Tablet Dental 5 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 7.49e-05 mg/mL ALOGPS logP 7.71 ALOGPS logP 8.16 Chemaxon logS -7 ALOGPS pKa (Strongest Acidic) 2.52 Chemaxon pKa (Strongest Basic) 1.84 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 89.49 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 174.48 m3·mol-1 Chemaxon Polarizability 54.71 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at September 22, 2017 14:32 / Updated at June 06, 2023 09:54