Mitogen-activated protein kinase kinase kinase 9

BE0004386ProteinHumansMAP3K9

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. It is acted on by 3 drugs in DrugBank.

Gene name
MAP3K9
UniProtKB entry
P80192Swiss-Prot
Residues / weight
1,104 residues · 121,893 Da
Also known as
2.7.11.25 · Mixed lineage kinase 1 · MLK1 · PRKE1

Resolves to

Protein
UniProtP80192UniProt nameM3K9_HUMAN
Gene
HGNCHGNC:6861NCBI Gene4293GenBank33591094GeneCardsMAP3K9
Pharmacology
IUPHAR/GtoPdb2084KEGGhsa:4293
Structure
PDB3DTCPDB4UY9
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase 9, how selective are they, and which programs against it are still in active trials?

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