Small conductance calcium-activated potassium channel protein 1

BE0004425ProteinHumansKCNN1

Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:17142458, PubMed:8781233, PubMed:9287325). It is acted on by 5 drugs in DrugBank.

Gene name
KCNN1
UniProtKB entry
Q92952Swiss-Prot
Cellular location
Membrane
Residues / weight
543 residues · 59,987 Da
Also known as
hSK1 · KCa2.1 · SK · SK1 · SKCa 1

Resolves to

Protein
UniProtQ92952UniProt nameKCNN1_HUMAN
Gene
HGNCHGNC:6290NCBI Gene3780GenBank1575661GeneCardsKCNN1
Pharmacology
IUPHAR/GtoPdb381KEGGhsa:3780
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Small conductance calcium-activated potassium channel protein 1, how selective are they, and which programs against it are still in active trials?

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