U6 snRNA-associated Sm-like protein LSm6

BE0004434ProteinHumansLSM6

Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). It is acted on by 3 drugs in DrugBank.

Gene name: LSM6
UniProtKB entry: P62312Swiss-Prot
Cellular location: Cytoplasm
Residues / weight: 80 residues · 9,128 Da

Resolves to

Protein

UniProtP62312UniProt nameLSM6_HUMAN

Gene

HGNCHGNC:17017NCBI Gene11157GeneCardsLSM6

Pharmacology

KEGGhsa:11157

Structure

PDB3JCRPDB5O9ZPDB6AH0

Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action

8GO termsFunction, process and component, as structured annotations

1Pfam domainDomain architecture mapped to Pfam families and clans

11+ReferencesStructured and connected to the statements they support

Which approved drugs act on U6 snRNA-associated Sm-like protein LSm6, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OS Sign in to your account

Create a free account or log in to explore the full data card.

Create Account