Diphthine methyl ester synthase

BE0004441ProteinHumansDPH5

S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. It is acted on by 1 drug in DrugBank.

Gene name
DPH5
UniProtKB entry
Q9H2P9Swiss-Prot
Residues / weight
285 residues · 31,651 Da
Also known as
2.1.1.314 · Diphthamide biosynthesis methyltransferase

Resolves to

Protein
UniProtQ9H2P9UniProt nameDPH5_HUMAN
Gene
HGNCHGNC:24270NCBI Gene51611GeneCardsDPH5
Pharmacology
KEGGhsa:51611
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Diphthine methyl ester synthase, and which indications are they being tested in?

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